(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone

(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone

Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological remodeling of all tissues. However, certain MMPs, s...

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Hlavní autoři: Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Fulvio Loiodice, Paolo Tortorella
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2021-01-01
Edice:Pharmaceuticals
Témata:
Matrix Metalloproteinase inhibitors
bone targeting
bisphosphonates
antitumor agents
skeletal malignancies
On-line přístup:https://www.mdpi.com/1424-8247/14/2/85

Internet

https://www.mdpi.com/1424-8247/14/2/85

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