A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas
The development of potent and selective therapeutic approaches to glioblastoma (GBM) requires the identification of molecular pathways that critically regulate the survival and proliferation of GBM. Glioblastoma stem-like cells (GSCs) possess stem-cell-like properties, self-renewal, and differentiat...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/4/473 |
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| author | Yukiko Nakahara Hiroshi Ito Hiroki Namikawa Takashi Furukawa Fumitaka Yoshioka Atsushi Ogata Jun Masuoka Tatsuya Abe |
| author_facet | Yukiko Nakahara Hiroshi Ito Hiroki Namikawa Takashi Furukawa Fumitaka Yoshioka Atsushi Ogata Jun Masuoka Tatsuya Abe |
| author_sort | Yukiko Nakahara |
| collection | DOAJ |
| description | The development of potent and selective therapeutic approaches to glioblastoma (GBM) requires the identification of molecular pathways that critically regulate the survival and proliferation of GBM. Glioblastoma stem-like cells (GSCs) possess stem-cell-like properties, self-renewal, and differentiation into multiple neural cell lineages. From a clinical point of view, GSCs have been reported to resist radiation and chemotherapy. GSCs are influenced by the microenvironment, especially the hypoxic condition. N-myc downstream-regulated gene 1 (NDRG1) is a tumor suppressor with the potential to suppress the proliferation, invasion, and migration of cancer cells. Previous studies have reported that deregulated expression of NDRG1 affects tumor growth and clinical outcomes of patients with GBM. This literature review aimed to clarify the critical role of NDRG1 in tumorigenesis and acquirement of resistance for anti-GBM therapies, further to discussing the possibility and efficacy of NDRG1 as a novel target of treatment for GBM. The present review was conducted by searching the PubMed and Scopus databases. The search was conducted in February 2022. We review current knowledge on the regulation and signaling of NDRG1 in neuro-oncology. Finally, the role of NDRG1 in GBM and potential clinical applications are discussed. |
| first_indexed | 2024-03-09T11:05:19Z |
| format | Article |
| id | doaj.art-9b44b1d9bcf04a1194990a1412046519 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T11:05:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9b44b1d9bcf04a1194990a14120465192023-12-01T00:59:44ZengMDPI AGBrain Sciences2076-34252022-04-0112447310.3390/brainsci12040473A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and GlioblastomasYukiko Nakahara0Hiroshi Ito1Hiroki Namikawa2Takashi Furukawa3Fumitaka Yoshioka4Atsushi Ogata5Jun Masuoka6Tatsuya Abe7Department of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanDepartment of Neurosurgery, Saga University, Saga 849-8501, JapanThe development of potent and selective therapeutic approaches to glioblastoma (GBM) requires the identification of molecular pathways that critically regulate the survival and proliferation of GBM. Glioblastoma stem-like cells (GSCs) possess stem-cell-like properties, self-renewal, and differentiation into multiple neural cell lineages. From a clinical point of view, GSCs have been reported to resist radiation and chemotherapy. GSCs are influenced by the microenvironment, especially the hypoxic condition. N-myc downstream-regulated gene 1 (NDRG1) is a tumor suppressor with the potential to suppress the proliferation, invasion, and migration of cancer cells. Previous studies have reported that deregulated expression of NDRG1 affects tumor growth and clinical outcomes of patients with GBM. This literature review aimed to clarify the critical role of NDRG1 in tumorigenesis and acquirement of resistance for anti-GBM therapies, further to discussing the possibility and efficacy of NDRG1 as a novel target of treatment for GBM. The present review was conducted by searching the PubMed and Scopus databases. The search was conducted in February 2022. We review current knowledge on the regulation and signaling of NDRG1 in neuro-oncology. Finally, the role of NDRG1 in GBM and potential clinical applications are discussed.https://www.mdpi.com/2076-3425/12/4/473N-myc downstream-regulated gene 1glioblastomaglioblastoma stem-like cells |
| spellingShingle | Yukiko Nakahara Hiroshi Ito Hiroki Namikawa Takashi Furukawa Fumitaka Yoshioka Atsushi Ogata Jun Masuoka Tatsuya Abe A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas Brain Sciences N-myc downstream-regulated gene 1 glioblastoma glioblastoma stem-like cells |
| title | A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas |
| title_full | A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas |
| title_fullStr | A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas |
| title_full_unstemmed | A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas |
| title_short | A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas |
| title_sort | tumor suppressor gene n myc downstream regulated gene 1 ndrg1 in gliomas and glioblastomas |
| topic | N-myc downstream-regulated gene 1 glioblastoma glioblastoma stem-like cells |
| url | https://www.mdpi.com/2076-3425/12/4/473 |
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