Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review
Recently, there have been investigations on metformin (Met) as a potential treatment for bone diseases such as osteoporosis, as researchers have outlined that type 2 diabetes mellitus (T2DM) poses an increased risk of fractures. Hence, this systematic review was conducted according to the 2020 PRISM...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/14/4193 |
| _version_ | 1797446159688531968 |
|---|---|
| author | Darren Kin Wai Loh Amudha Kadirvelu Narendra Pamidi |
| author_facet | Darren Kin Wai Loh Amudha Kadirvelu Narendra Pamidi |
| author_sort | Darren Kin Wai Loh |
| collection | DOAJ |
| description | Recently, there have been investigations on metformin (Met) as a potential treatment for bone diseases such as osteoporosis, as researchers have outlined that type 2 diabetes mellitus (T2DM) poses an increased risk of fractures. Hence, this systematic review was conducted according to the 2020 PRISMA guidelines to evaluate the evidence that supports the bone-protective effects of metformin on male animal models with T2DM. Five databases—Google Scholar, PubMed, Wiley Online Library, SCOPUS, and ScienceDirect—were used to search for original randomized controlled trials published in English with relevant keywords. The search identified 18 articles that matched the inclusion criteria and illustrated the effects of Met on bone. This study demonstrates that Met improved bone density and reduced the effects of T2DM on adiposity formation in the animal models. Further research is needed to pinpoint the optimal dosage of Met required to exhibit these therapeutic effects. |
| first_indexed | 2024-03-09T13:36:13Z |
| format | Article |
| id | doaj.art-9b44bc017fb0492e996a89e624b0a07c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:36:13Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9b44bc017fb0492e996a89e624b0a07c2023-11-30T21:11:38ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011114419310.3390/jcm11144193Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic ReviewDarren Kin Wai Loh0Amudha Kadirvelu1Narendra Pamidi2Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, MalaysiaJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, MalaysiaJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, MalaysiaRecently, there have been investigations on metformin (Met) as a potential treatment for bone diseases such as osteoporosis, as researchers have outlined that type 2 diabetes mellitus (T2DM) poses an increased risk of fractures. Hence, this systematic review was conducted according to the 2020 PRISMA guidelines to evaluate the evidence that supports the bone-protective effects of metformin on male animal models with T2DM. Five databases—Google Scholar, PubMed, Wiley Online Library, SCOPUS, and ScienceDirect—were used to search for original randomized controlled trials published in English with relevant keywords. The search identified 18 articles that matched the inclusion criteria and illustrated the effects of Met on bone. This study demonstrates that Met improved bone density and reduced the effects of T2DM on adiposity formation in the animal models. Further research is needed to pinpoint the optimal dosage of Met required to exhibit these therapeutic effects.https://www.mdpi.com/2077-0383/11/14/4193metformintype 2 diabetesbone densityadiposityanimal |
| spellingShingle | Darren Kin Wai Loh Amudha Kadirvelu Narendra Pamidi Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review Journal of Clinical Medicine metformin type 2 diabetes bone density adiposity animal |
| title | Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review |
| title_full | Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review |
| title_fullStr | Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review |
| title_full_unstemmed | Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review |
| title_short | Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review |
| title_sort | effects of metformin on bone mineral density and adiposity associated pathways in animal models with type 2 diabetes mellitus a systematic review |
| topic | metformin type 2 diabetes bone density adiposity animal |
| url | https://www.mdpi.com/2077-0383/11/14/4193 |
| work_keys_str_mv | AT darrenkinwailoh effectsofmetforminonbonemineraldensityandadiposityassociatedpathwaysinanimalmodelswithtype2diabetesmellitusasystematicreview AT amudhakadirvelu effectsofmetforminonbonemineraldensityandadiposityassociatedpathwaysinanimalmodelswithtype2diabetesmellitusasystematicreview AT narendrapamidi effectsofmetforminonbonemineraldensityandadiposityassociatedpathwaysinanimalmodelswithtype2diabetesmellitusasystematicreview |