Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review
This systematic review aimed to assess whether dental caries is associated with oxidative salivary stress. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenGrey, and Google Scholar, without restrictions on the date of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/9/858 |
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| author | Yago Gecy de Sousa Né Deborah Ribeiro Frazão Leonardo Oliveira Bittencourt Nathalia Carolina Fernandes Fagundes Guido Marañón-Vásquez Maria Elena Crespo-Lopez Lucianne Cople Maia Rafael Rodrigues Lima |
| author_facet | Yago Gecy de Sousa Né Deborah Ribeiro Frazão Leonardo Oliveira Bittencourt Nathalia Carolina Fernandes Fagundes Guido Marañón-Vásquez Maria Elena Crespo-Lopez Lucianne Cople Maia Rafael Rodrigues Lima |
| author_sort | Yago Gecy de Sousa Né |
| collection | DOAJ |
| description | This systematic review aimed to assess whether dental caries is associated with oxidative salivary stress. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenGrey, and Google Scholar, without restrictions on the date of publication and language. The acronym PECO was used, in which the participants (P) were children and adolescents exposed (E) to dental caries compared (C) to those without dental caries, with the outcome (O) of modulation of oxidative biochemical parameters. After the search retrieval, the duplicates were removed, and the articles were evaluated by title and abstract, following the inclusion and exclusion criteria. Then, the papers were read and thoroughly assessed. After selection, the risk of bias assessment and qualitative synthesis were performed using the Newcastle-Ottawa Scale (NOS) for observational studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to assess the level of evidence. A total of 5790 studies were found, and 30 articles were considered eligible and were included for the qualitative synthesis and the level of evidence assessment. The studies showed an imbalance of the antioxidant and pro-oxidant parameters in individuals with dental caries, with primarily increases in both total antioxidant capacity and lipid peroxidation. Most articles showed a low risk of bias, having comparability as the main issue. When exploring through GRADE, a very low level of evidence was found. It was possible to observe an association between oxidative stress and dental caries, showing a disbalance of antioxidants and pro-oxidants, but the evidence level was still very low. |
| first_indexed | 2024-03-09T23:10:55Z |
| format | Article |
| id | doaj.art-9b46a5b93520490aa1359bb6b65870db |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:10:55Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-9b46a5b93520490aa1359bb6b65870db2023-11-23T17:44:56ZengMDPI AGMetabolites2218-19892022-09-0112985810.3390/metabo12090858Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic ReviewYago Gecy de Sousa Né0Deborah Ribeiro Frazão1Leonardo Oliveira Bittencourt2Nathalia Carolina Fernandes Fagundes3Guido Marañón-Vásquez4Maria Elena Crespo-Lopez5Lucianne Cople Maia6Rafael Rodrigues Lima7Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, BrazilSchool of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, CanadaDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, RJ, BrazilLaboratory of Molecular Pharmacology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, BrazilDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, RJ, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belem 66075-110, PA, BrazilThis systematic review aimed to assess whether dental caries is associated with oxidative salivary stress. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenGrey, and Google Scholar, without restrictions on the date of publication and language. The acronym PECO was used, in which the participants (P) were children and adolescents exposed (E) to dental caries compared (C) to those without dental caries, with the outcome (O) of modulation of oxidative biochemical parameters. After the search retrieval, the duplicates were removed, and the articles were evaluated by title and abstract, following the inclusion and exclusion criteria. Then, the papers were read and thoroughly assessed. After selection, the risk of bias assessment and qualitative synthesis were performed using the Newcastle-Ottawa Scale (NOS) for observational studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to assess the level of evidence. A total of 5790 studies were found, and 30 articles were considered eligible and were included for the qualitative synthesis and the level of evidence assessment. The studies showed an imbalance of the antioxidant and pro-oxidant parameters in individuals with dental caries, with primarily increases in both total antioxidant capacity and lipid peroxidation. Most articles showed a low risk of bias, having comparability as the main issue. When exploring through GRADE, a very low level of evidence was found. It was possible to observe an association between oxidative stress and dental caries, showing a disbalance of antioxidants and pro-oxidants, but the evidence level was still very low.https://www.mdpi.com/2218-1989/12/9/858dental cariessalivaoxidative stresssystematic review |
| spellingShingle | Yago Gecy de Sousa Né Deborah Ribeiro Frazão Leonardo Oliveira Bittencourt Nathalia Carolina Fernandes Fagundes Guido Marañón-Vásquez Maria Elena Crespo-Lopez Lucianne Cople Maia Rafael Rodrigues Lima Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review Metabolites dental caries saliva oxidative stress systematic review |
| title | Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review |
| title_full | Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review |
| title_fullStr | Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review |
| title_full_unstemmed | Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review |
| title_short | Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review |
| title_sort | are dental caries associated with oxidative stress in saliva in children and adolescents a systematic review |
| topic | dental caries saliva oxidative stress systematic review |
| url | https://www.mdpi.com/2218-1989/12/9/858 |
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