Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients
Objective Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is a prevalent problem affecting hemodialysis (HD) patients. Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism. We explored the ability of r...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231204475 |
| _version_ | 1797659126984081408 |
|---|---|
| author | Jie Song Xiaojun Chen Linshan Zhou Weihong Yu Hong Liu Fang Yuan |
| author_facet | Jie Song Xiaojun Chen Linshan Zhou Weihong Yu Hong Liu Fang Yuan |
| author_sort | Jie Song |
| collection | DOAJ |
| description | Objective Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is a prevalent problem affecting hemodialysis (HD) patients. Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism. We explored the ability of roxadustat to increase the hemoglobin (Hb) concentration in ESA-hyporesponsive patients undergoing HD and assessed its effect on iron metabolism and inflammation. Methods This prospective study included 30 patients with ESA-hyporesponsive anemia who had been undergoing stable dialysis. All patients received roxadustat three times per week for 24 weeks. The primary endpoint was the mean change in Hb from baseline to the average level over weeks 20 to 24. Iron metabolism markers, C-reactive protein, interleukin (IL)-6, and safety were also assessed. Results At week 24, roxadustat treatment resulted in a 2.5 ± 1.3 g/dL increase in the Hb level. In total, 28 of 30 patients (93.3%) had an Hb level increase of more than 1.0 g/dL from baseline. Seventeen patients (56.7%) met the endpoint, with a mean Hb level of at least 10.0 g/dL. Iron metabolism and IL-6 levels were also improved. Conclusions Oral roxadustat is effective for ESA-hyporesponsive anemia in maintenance HD patients and may also improve iron metabolism and IL-6 levels. |
| first_indexed | 2024-03-11T18:10:21Z |
| format | Article |
| id | doaj.art-9b47b8a74016460ba6d093f5a058906f |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-11T18:10:21Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-9b47b8a74016460ba6d093f5a058906f2023-10-16T16:03:38ZengSAGE PublishingJournal of International Medical Research1473-23002023-10-015110.1177/03000605231204475Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patientsJie SongXiaojun ChenLinshan ZhouWeihong YuHong LiuFang YuanObjective Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is a prevalent problem affecting hemodialysis (HD) patients. Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism. We explored the ability of roxadustat to increase the hemoglobin (Hb) concentration in ESA-hyporesponsive patients undergoing HD and assessed its effect on iron metabolism and inflammation. Methods This prospective study included 30 patients with ESA-hyporesponsive anemia who had been undergoing stable dialysis. All patients received roxadustat three times per week for 24 weeks. The primary endpoint was the mean change in Hb from baseline to the average level over weeks 20 to 24. Iron metabolism markers, C-reactive protein, interleukin (IL)-6, and safety were also assessed. Results At week 24, roxadustat treatment resulted in a 2.5 ± 1.3 g/dL increase in the Hb level. In total, 28 of 30 patients (93.3%) had an Hb level increase of more than 1.0 g/dL from baseline. Seventeen patients (56.7%) met the endpoint, with a mean Hb level of at least 10.0 g/dL. Iron metabolism and IL-6 levels were also improved. Conclusions Oral roxadustat is effective for ESA-hyporesponsive anemia in maintenance HD patients and may also improve iron metabolism and IL-6 levels.https://doi.org/10.1177/03000605231204475 |
| spellingShingle | Jie Song Xiaojun Chen Linshan Zhou Weihong Yu Hong Liu Fang Yuan Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients Journal of International Medical Research |
| title | Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients |
| title_full | Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients |
| title_fullStr | Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients |
| title_full_unstemmed | Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients |
| title_short | Roxadustat treatment for erythropoiesis-stimulating agent-hyporesponsive anemia in maintenance hemodialysis patients |
| title_sort | roxadustat treatment for erythropoiesis stimulating agent hyporesponsive anemia in maintenance hemodialysis patients |
| url | https://doi.org/10.1177/03000605231204475 |
| work_keys_str_mv | AT jiesong roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients AT xiaojunchen roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients AT linshanzhou roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients AT weihongyu roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients AT hongliu roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients AT fangyuan roxadustattreatmentforerythropoiesisstimulatingagenthyporesponsiveanemiainmaintenancehemodialysispatients |