Milestones in Bacillus subtilis sporulation research
Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2020-11-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2020a-riley-microbial-cell/ |
| _version_ | 1818427398343884800 |
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| author | Eammon P. Riley Corinna Schwarz Alan I. Derman Javier Lopez-Garrido |
| author_facet | Eammon P. Riley Corinna Schwarz Alan I. Derman Javier Lopez-Garrido |
| author_sort | Eammon P. Riley |
| collection | DOAJ |
| description | Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chronology that spans more than one hundred eighty years. We detail how cell-specific gene expression has been harnessed to investigate the existence and function of intercellular proteinaceous channels in sporulating cells, and we illustrate the rapid progress in our understanding of the cell biology of sporulation in recent years using the process of chromosome translocation as a storyline. Finally, we sketch general aspects of sporulation that remain largely unexplored, and that we envision will be fruitful areas of future research. |
| first_indexed | 2024-12-14T14:45:06Z |
| format | Article |
| id | doaj.art-9b481d197d834fbca1ddc3678ac20366 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-14T14:45:06Z |
| publishDate | 2020-11-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-9b481d197d834fbca1ddc3678ac203662022-12-21T22:57:18ZengShared Science Publishers OGMicrobial Cell2311-26382020-11-018111610.15698/mic2021.01.739Milestones in Bacillus subtilis sporulation researchEammon P. Riley0Corinna Schwarz1Alan I. Derman2Javier Lopez-Garrido3Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.Max Planck Institute for Evolutionary Biology, Plön, Germany.Max Planck Institute for Evolutionary Biology, Plön, Germany.Max Planck Institute for Evolutionary Biology, Plön, Germany.Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chronology that spans more than one hundred eighty years. We detail how cell-specific gene expression has been harnessed to investigate the existence and function of intercellular proteinaceous channels in sporulating cells, and we illustrate the rapid progress in our understanding of the cell biology of sporulation in recent years using the process of chromosome translocation as a storyline. Finally, we sketch general aspects of sporulation that remain largely unexplored, and that we envision will be fruitful areas of future research.http://microbialcell.com/researcharticles/2020a-riley-microbial-cell/bacillus subtilissporulationgeneticsspoiiiespoiiiaspoiiqsporulation history |
| spellingShingle | Eammon P. Riley Corinna Schwarz Alan I. Derman Javier Lopez-Garrido Milestones in Bacillus subtilis sporulation research Microbial Cell bacillus subtilis sporulation genetics spoiiie spoiiia spoiiq sporulation history |
| title | Milestones in Bacillus subtilis sporulation research |
| title_full | Milestones in Bacillus subtilis sporulation research |
| title_fullStr | Milestones in Bacillus subtilis sporulation research |
| title_full_unstemmed | Milestones in Bacillus subtilis sporulation research |
| title_short | Milestones in Bacillus subtilis sporulation research |
| title_sort | milestones in bacillus subtilis sporulation research |
| topic | bacillus subtilis sporulation genetics spoiiie spoiiia spoiiq sporulation history |
| url | http://microbialcell.com/researcharticles/2020a-riley-microbial-cell/ |
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