Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical...

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Bibliographic Details
Main Authors: Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar
Format: Article
Language:English
Published: Karger Publishers 2022-09-01
Series:Case Reports in Nephrology and Dialysis
Subjects:
Online Access:https://www.karger.com/Article/FullText/526323
Description
Summary:Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.
ISSN:2296-9705