Nanomaterials as Novel Cardiovascular Theranostics
Cardiovascular diseases (CVDs) are a group of conditions associated with heart and blood vessels and are considered the leading cause of death globally. Coronary heart disease, atherosclerosis, myocardial infarction represents the CVDs. Since CVDs are associated with a series of pathophysiological c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/3/348 |
| _version_ | 1797412716396150784 |
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| author | Rajasekharreddy Pala Subhaswaraj Pattnaik Siddhardha Busi Surya M. Nauli |
| author_facet | Rajasekharreddy Pala Subhaswaraj Pattnaik Siddhardha Busi Surya M. Nauli |
| author_sort | Rajasekharreddy Pala |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are a group of conditions associated with heart and blood vessels and are considered the leading cause of death globally. Coronary heart disease, atherosclerosis, myocardial infarction represents the CVDs. Since CVDs are associated with a series of pathophysiological conditions with an alarming mortality and morbidity rate, early diagnosis and appropriate therapeutic approaches are critical for saving patients’ lives. Conventionally, diagnostic tools are employed to detect disease conditions, whereas therapeutic drug candidates are administered to mitigate diseases. However, the advent of nanotechnological platforms has revolutionized the current understanding of pathophysiology and therapeutic measures. The concept of combinatorial therapy using both diagnosis and therapeutics through a single platform is known as theranostics. Nano-based theranostics are widely used in cancer detection and treatment, as evident from pre-clinical and clinical studies. Nanotheranostics have gained considerable attention for the efficient management of CVDs. The differential physicochemical properties of engineered nanoparticles have been exploited for early diagnosis and therapy of atherosclerosis, myocardial infarction and aneurysms. Herein, we provided the information on the evolution of nano-based theranostics to detect and treat CVDs such as atherosclerosis, myocardial infarction, and angiogenesis. The review also aims to provide novel avenues on how nanotherapeutics’ trending concept could transform our conventional diagnostic and therapeutic tools in the near future. |
| first_indexed | 2024-03-09T05:07:12Z |
| format | Article |
| id | doaj.art-9b4bd6bec92747d79de2c7369478b3b5 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T05:07:12Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9b4bd6bec92747d79de2c7369478b3b52023-12-03T12:53:33ZengMDPI AGPharmaceutics1999-49232021-03-0113334810.3390/pharmaceutics13030348Nanomaterials as Novel Cardiovascular TheranosticsRajasekharreddy Pala0Subhaswaraj Pattnaik1Siddhardha Busi2Surya M. Nauli3Department of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University, Irvine, CA 92618, USADepartment of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University, Irvine, CA 92618, USACardiovascular diseases (CVDs) are a group of conditions associated with heart and blood vessels and are considered the leading cause of death globally. Coronary heart disease, atherosclerosis, myocardial infarction represents the CVDs. Since CVDs are associated with a series of pathophysiological conditions with an alarming mortality and morbidity rate, early diagnosis and appropriate therapeutic approaches are critical for saving patients’ lives. Conventionally, diagnostic tools are employed to detect disease conditions, whereas therapeutic drug candidates are administered to mitigate diseases. However, the advent of nanotechnological platforms has revolutionized the current understanding of pathophysiology and therapeutic measures. The concept of combinatorial therapy using both diagnosis and therapeutics through a single platform is known as theranostics. Nano-based theranostics are widely used in cancer detection and treatment, as evident from pre-clinical and clinical studies. Nanotheranostics have gained considerable attention for the efficient management of CVDs. The differential physicochemical properties of engineered nanoparticles have been exploited for early diagnosis and therapy of atherosclerosis, myocardial infarction and aneurysms. Herein, we provided the information on the evolution of nano-based theranostics to detect and treat CVDs such as atherosclerosis, myocardial infarction, and angiogenesis. The review also aims to provide novel avenues on how nanotherapeutics’ trending concept could transform our conventional diagnostic and therapeutic tools in the near future.https://www.mdpi.com/1999-4923/13/3/348diagnosisbioimagingtherapeuticsnanotheranosticsCVDs |
| spellingShingle | Rajasekharreddy Pala Subhaswaraj Pattnaik Siddhardha Busi Surya M. Nauli Nanomaterials as Novel Cardiovascular Theranostics Pharmaceutics diagnosis bioimaging therapeutics nanotheranostics CVDs |
| title | Nanomaterials as Novel Cardiovascular Theranostics |
| title_full | Nanomaterials as Novel Cardiovascular Theranostics |
| title_fullStr | Nanomaterials as Novel Cardiovascular Theranostics |
| title_full_unstemmed | Nanomaterials as Novel Cardiovascular Theranostics |
| title_short | Nanomaterials as Novel Cardiovascular Theranostics |
| title_sort | nanomaterials as novel cardiovascular theranostics |
| topic | diagnosis bioimaging therapeutics nanotheranostics CVDs |
| url | https://www.mdpi.com/1999-4923/13/3/348 |
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