Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion
Transcription factors (TFs) modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular action: they function as transcription repres...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2021-12-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2021003 |
| _version_ | 1797635826843123712 |
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| author | Fang Chengli Zhang Yu |
| author_facet | Fang Chengli Zhang Yu |
| author_sort | Fang Chengli |
| collection | DOAJ |
| description | Transcription factors (TFs) modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular action: they function as transcription repressors under normal circumstances, but rapidly transform to transcription activators under various cellular triggers, including oxidative stress, imbalance of cellular metal ions, and antibiotic challenge. The promoters regulated by MerR TFs typically contain an abnormal long spacer between the –35 and –10 elements, where MerR TFs bind and regulate transcription activity through unique mechanisms. In this review, we summarize the function, ligand reception, DNA recognition, and molecular mechanism of transcription regulation of MerR-family TFs. |
| first_indexed | 2024-03-11T12:25:54Z |
| format | Article |
| id | doaj.art-9b4bffd305fa4e668600ceb607cd247f |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:25:54Z |
| publishDate | 2021-12-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-9b4bffd305fa4e668600ceb607cd247f2023-11-06T09:01:01ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452021-12-0154253610.3724/abbs.202100320d259ccBacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortionFang Chengli0Zhang Yu1["Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China"]["Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China"]Transcription factors (TFs) modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular action: they function as transcription repressors under normal circumstances, but rapidly transform to transcription activators under various cellular triggers, including oxidative stress, imbalance of cellular metal ions, and antibiotic challenge. The promoters regulated by MerR TFs typically contain an abnormal long spacer between the –35 and –10 elements, where MerR TFs bind and regulate transcription activity through unique mechanisms. In this review, we summarize the function, ligand reception, DNA recognition, and molecular mechanism of transcription regulation of MerR-family TFs.https://www.sciengine.com/doi/10.3724/abbs.2021003RNA polymerasegene transcriptiongene expressiontranscription factorMerR |
| spellingShingle | Fang Chengli Zhang Yu Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion Acta Biochimica et Biophysica Sinica RNA polymerase gene transcription gene expression transcription factor MerR |
| title | Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion |
| title_full | Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion |
| title_fullStr | Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion |
| title_full_unstemmed | Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion |
| title_short | Bacterial MerR family transcription regulators: activation<?A3B2 ACK?>by distortion |
| title_sort | bacterial merr family transcription regulators activation a3b2 ack by distortion |
| topic | RNA polymerase gene transcription gene expression transcription factor MerR |
| url | https://www.sciengine.com/doi/10.3724/abbs.2021003 |
| work_keys_str_mv | AT fangchengli bacterialmerrfamilytranscriptionregulatorsactivationa3b2ackbydistortion AT zhangyu bacterialmerrfamilytranscriptionregulatorsactivationa3b2ackbydistortion |