Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.

Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.

BACKGROUND: Individual variances usually affect drug metabolism and disposition, and hence result in either ineffectiveness or toxicity of a drug. In addition to genetic polymorphism, the multiple confounding factors of lifestyles, such as dietary preferences, contribute partially to individual vari...

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Main Authors: Linsheng Liu, Bei Cao, Jiye Aa, Tian Zheng, Jian Shi, Mengjie Li, Xinwen Wang, Chunyan Zhao, Wenjing Xiao, Xiaoyi Yu, Runbin Sun, Rongrong Gu, Jun Zhou, Liang Wu, Gang Hao, Xuanxuan Zhu, Guangji Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3422234?pdf=render

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