Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population
Abstract Background: Vitiligo is characterized by an autoimmune response targeting melanocytes, thus resulting in skin depigmentation. There are several genetic components involved in the development of vitiligo, of which various gene polymorphisms are currently considered as risk factors. For exam...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2022-11-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600710&lng=en&tlng=en |
| _version_ | 1811313876601405440 |
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| author | Mauricio Andrés Salinas-Santander Víctor de Jesús Suárez-Valencia Mayela del Ángel-Martínez David Emmanuel Kubelis-Lopez Natalia Aranza Zapata-Salazar Jorge Alejandro Ocampo-Garza Jorge Ocampo-Candiani |
| author_facet | Mauricio Andrés Salinas-Santander Víctor de Jesús Suárez-Valencia Mayela del Ángel-Martínez David Emmanuel Kubelis-Lopez Natalia Aranza Zapata-Salazar Jorge Alejandro Ocampo-Garza Jorge Ocampo-Candiani |
| author_sort | Mauricio Andrés Salinas-Santander |
| collection | DOAJ |
| description | Abstract Background: Vitiligo is characterized by an autoimmune response targeting melanocytes, thus resulting in skin depigmentation. There are several genetic components involved in the development of vitiligo, of which various gene polymorphisms are currently considered as risk factors. For example, the CTLA4 (T-lymphocyte antigen 4) +49A/G (rs231775) and CT60 (rs3087243) gene variants have been associated with a predisposition for autoimmune diseases in different populations; however, their involvement in the development of vitiligo remains controversial. Objective: We evaluated the association between vitiligo and the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants in a Mexican population. Methods: A total of 116 vitiligo patients and 117 control subjects from northeast Mexico were included in the study and analyzed through PCR-RFLP to determine whether there is an association between vitiligo and CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants. Results: No statistical difference was observed for both gene polymorphisms between vitiligo patients and controls (p > 0.05). Otherwise, vitiligo activity, family history of vitiligo, personal history of autoimmune diseases, or sex did not show any difference (p > 0.05). Conclusion: As suggested by the analysis of a northeastern Mexican population, the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants do not constitute a risk factor in the development of vitiligo. |
| first_indexed | 2024-04-13T11:02:16Z |
| format | Article |
| id | doaj.art-9b4df1d9508545f5ac493ae611b3224b |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-13T11:02:16Z |
| publishDate | 2022-11-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-9b4df1d9508545f5ac493ae611b3224b2022-12-22T02:49:23ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-11-0197671071510.1016/j.abd.2021.10.012Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican populationMauricio Andrés Salinas-Santanderhttps://orcid.org/0000-0002-5439-5787Víctor de Jesús Suárez-Valenciahttps://orcid.org/0000-0002-4963-2100Mayela del Ángel-Martínezhttps://orcid.org/0000-0002-7715-8039David Emmanuel Kubelis-Lopezhttps://orcid.org/0000-0002-9675-7918Natalia Aranza Zapata-Salazarhttps://orcid.org/0000-0002-7562-3961Jorge Alejandro Ocampo-Garzahttps://orcid.org/0000-0002-1307-3407Jorge Ocampo-Candianihttps://orcid.org/0000-0002-0213-0031Abstract Background: Vitiligo is characterized by an autoimmune response targeting melanocytes, thus resulting in skin depigmentation. There are several genetic components involved in the development of vitiligo, of which various gene polymorphisms are currently considered as risk factors. For example, the CTLA4 (T-lymphocyte antigen 4) +49A/G (rs231775) and CT60 (rs3087243) gene variants have been associated with a predisposition for autoimmune diseases in different populations; however, their involvement in the development of vitiligo remains controversial. Objective: We evaluated the association between vitiligo and the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants in a Mexican population. Methods: A total of 116 vitiligo patients and 117 control subjects from northeast Mexico were included in the study and analyzed through PCR-RFLP to determine whether there is an association between vitiligo and CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants. Results: No statistical difference was observed for both gene polymorphisms between vitiligo patients and controls (p > 0.05). Otherwise, vitiligo activity, family history of vitiligo, personal history of autoimmune diseases, or sex did not show any difference (p > 0.05). Conclusion: As suggested by the analysis of a northeastern Mexican population, the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants do not constitute a risk factor in the development of vitiligo.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600710&lng=en&tlng=enCTLA4, gene variantsMexican populationVitiligo |
| spellingShingle | Mauricio Andrés Salinas-Santander Víctor de Jesús Suárez-Valencia Mayela del Ángel-Martínez David Emmanuel Kubelis-Lopez Natalia Aranza Zapata-Salazar Jorge Alejandro Ocampo-Garza Jorge Ocampo-Candiani Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population Anais Brasileiros de Dermatologia CTLA4, gene variants Mexican population Vitiligo |
| title | Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population |
| title_full | Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population |
| title_fullStr | Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population |
| title_full_unstemmed | Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population |
| title_short | Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population |
| title_sort | association between the ctla4 49a g rs231775 and ct60 rs3087243 gene variants with vitiligo study on a mexican population |
| topic | CTLA4, gene variants Mexican population Vitiligo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600710&lng=en&tlng=en |
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