Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study

Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study

Background: NT-proBNP and GDF-15 are established blood-derived biomarkers for risk assessment in pulmonary hypertension (PH), despite limited sensitivity and specificity. Apelin has a crucial function in endothelial homeostasis, thus it might represent a new biomarker for PH. However, there are nume...

Full description

Bibliographic Details
Main Authors:	Vasile Foris, Gabor Kovacs, Alexander Avian, Zoltán Bálint, Philipp Douschan, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Horst Olschewski
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Physiology
Subjects:	apelin-17 NT-proBNP GDF-15 blood derived biomarker diagnosis idiopathic pulmonary arterial hypertension
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.986295/full

Similar Items

Imatinib for right heart failure in COPD
by: Philipp Douschan, et al.
Published: (2018-12-01)

Use of ECG and Other Simple Non-Invasive Tools to Assess Pulmonary Hypertension.
by: Gabor Kovacs, et al.
Published: (2016-01-01)

Advanced interstitial lung fibrosis with emphysema and pulmonary hypertension with no evidence for interstitial lung disease on high resolution CT
by: Vasile Foris, et al.
Published: (2019-07-01)

Diagnostic value of NT–PRO BNP in cardiogenic and non cardiogenic pleural effusions
by: Mohamed E. Abdalla, et al.
Published: (2012-07-01)

Impact of Left Ventricular Diastolic Dysfunction and Biomarkers on Pulmonary Hypertension in Patients with Severe Aortic Stenosis
by: Birutė Gumauskienė, et al.
Published: (2018-09-01)

NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population
by: Stefano Ciardullo, et al.
Published: (2022-11-01)

Serum level of apelin-13 negatively correlated with NT-proBNP in heart failure patients
by: Goidescu Cerasela Mihaela, et al.
Published: (2016-12-01)

Performance of the Abbott Architect Immuno-Chemiluminometric NT-proBNP Assay
by: Chin-Shern Lau, et al.
Published: (2022-05-01)

A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls
by: Ana Merino-Merino, et al.
Published: (2022-08-01)

N-terminal-pro-brain natriuretic peptide is decreased in insulin dependent gestational diabetes mellitus: a prospective cohort trial
by: Gottsauner-Wolf Michael, et al.
Published: (2011-04-01)

Clinical correlation between N-terminal pro-b-type natriuretic peptide and angiographic coronary atherosclerosis
by: Demóstenes G.L. Ribeiro, et al.
Published: (2014-06-01)

The prognostic value of the plasma N-terminal pro-brain natriuretic peptide level on all-cause death and major cardiovascular events in a community-based population
by: Zhu Q, et al.
Published: (2016-02-01)

Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspneaen with dyspnea
by: Zakaria Mukalla, et al.
Published: (2017-06-01)

Effect of feline characteristics on plasma N‐terminal‐prohormone B‐type natriuretic peptide concentration and comparison of a point‐of‐care test and an ELISA test
by: Sofia Hanås, et al.
Published: (2020-05-01)

Higher BNP/NT‐pro BNP levels stratify prognosis equally well in patients with and without heart failure: a meta‐analysis
by: Stefanie Hendricks, et al.
Published: (2022-10-01)

The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis
by: Susana Coimbra, et al.
Published: (2023-03-01)

Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study
by: Sonja Levy, et al.
Published: (2022-05-01)

Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19
by: Naghmeh Ziaie, et al.
Published: (2023-07-01)

N-TerminalPro-B-TypeNatriuretic Peptide For Detecting Early Cardiac Dysfunction in Patients with Thyroid Dysfunction
by: Makbule Ulusoy, et al.
Published: (2013-09-01)

Changes in Cardiac Levels of Caspase-8, Bcl-2 and NT-proBNP Following 4 Weeks of Aerobic Exercise in Diabetic Rats
by: Saeid Tanoorsaz, et al.
Published: (2017-12-01)

Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction
by: V. A. Vasylenko
Published: (2015-10-01)

N‐terminal pro brain natriuretic peptide reference values in community‐dwelling older adults
by: Ulrike Braisch, et al.
Published: (2022-06-01)

The Role of NT-proBNP in the Diagnosis of Ventricular Arrhythmias in Patients with Systemic
by: Lucian MURESAN, et al.
Published: (2017-06-01)

Influence of collaterals on the left ventricular end-diastolic pressure and serum NT-proBNP levels in patients with coronary chronic total occlusion
by: Fuad Samadov, et al.
Published: (2017-06-01)

N-terminal proBrain Natriuretic Peptide as Indicator of Left Ventricle Hypertrophy In Hypertensive Patients Compared with Left Ventricle Mass Index in Echocardiography
by: Mohammad Ariful Munir, et al.
Published: (2013-06-01)

Síndrome Hiperinflamatória como Mecanismo de Lesão Cardíaca
by: Silvia Moreira Ayub-Ferreira, et al.
Published: (2021-04-01)

NT-proBNP as predictor of major cardiac events after renal transplantation in patients with preserved left ventricular ejection fraction
by: Sebastian Schwab, et al.
Published: (2023-02-01)

N-Terminal Pro B-Type Natriuretic Peptide's Usefulness for Paroxysmal Atrial Fibrillation Detection Among Populations Carrying Cardiovascular Risk Factors
by: Elena Palà, et al.
Published: (2019-11-01)

Atrial Fibrillation, thromboembolic risk, and the potential role of the natriuretic peptides, a focus on BNP and NT-proBNP – A narrative review
by: Brian Kerr, et al.
Published: (2022-12-01)

Serum Pro‐N‐Cadherin Is a Marker of Subclinical Heart Failure in the General Population
by: Paul Durham Ferrell, et al.
Published: (2023-03-01)

Six-Month Predictive Value of Diuretic Resistance Formulas in Discharged Heart Failure Patients after an Acute Decompensation
by: Mauro Feola, et al.
Published: (2020-09-01)

Significance of NT-proBNP and High-Sensitivity Troponin in Friedreich Ataxia
by: Lise Legrand, et al.
Published: (2020-05-01)

Differences According to Age in the Diagnostic Performance of Cardiac Biomarkers to Predict Frailty in Patients with Acute Heart Failure
by: Lara Aguilar-Iglesias, et al.
Published: (2022-02-01)

Low-Level Elevations of Procalcitonin Are Associated with Increased Mortality in Acute Heart Failure Patients, Independent of Concomitant Infection
by: Fabrice F. Darche, et al.
Published: (2021-12-01)

NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis
by: Evangelos Christou, et al.
Published: (2022-06-01)

Heart failure with preserved ejection fraction in haemodialysis patients: prevalence, diagnosis, risk factors, prognosis
by: Xixi Yu, et al.
Published: (2023-10-01)

Longitudinal association between N-terminal B-type natriuretic peptide, anxiety and social support in patients with HFpEF: results from the multicentre randomized controlled Aldo-DHF trial
by: Marieke R. Wilke, et al.
Published: (2023-04-01)

N‐Terminal pro‐B‐type natriuretic peptide and stroke risk across a spectrum of cerebrovascular disease: The REasons for Geographic and Racial Differences in Stroke cohort
by: Kara K. Landry, et al.
Published: (2020-07-01)

Predictive values of clinical data,molecular biomarkers, and echocardiographic measurements in preterm infants with bronchopulmonary dysplasia
by: Huawei Wang, et al.
Published: (2023-02-01)

Relationship between NT-proBNP and the ejection fraction during intensive care variety in polytrauma patients with concomitant cardiac disorder
by: Svitlana Lutska, et al.
Published: (2021-10-01)