Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study

Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study

Background: NT-proBNP and GDF-15 are established blood-derived biomarkers for risk assessment in pulmonary hypertension (PH), despite limited sensitivity and specificity. Apelin has a crucial function in endothelial homeostasis, thus it might represent a new biomarker for PH. However, there are nume...

Full description

Bibliographic Details
Main Authors:	Vasile Foris, Gabor Kovacs, Alexander Avian, Zoltán Bálint, Philipp Douschan, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Horst Olschewski
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Physiology
Subjects:	apelin-17 NT-proBNP GDF-15 blood derived biomarker diagnosis idiopathic pulmonary arterial hypertension
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.986295/full

Similar Items

NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population
by: Stefano Ciardullo, et al.
Published: (2022-11-01)

Impact of Left Ventricular Diastolic Dysfunction and Biomarkers on Pulmonary Hypertension in Patients with Severe Aortic Stenosis
by: Birutė Gumauskienė, et al.
Published: (2018-09-01)

Performance of the Abbott Architect Immuno-Chemiluminometric NT-proBNP Assay
by: Chin-Shern Lau, et al.
Published: (2022-05-01)

A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls
by: Ana Merino-Merino, et al.
Published: (2022-08-01)

Higher BNP/NT‐pro BNP levels stratify prognosis equally well in patients with and without heart failure: a meta‐analysis
by: Stefanie Hendricks, et al.
Published: (2022-10-01)

The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis
by: Susana Coimbra, et al.
Published: (2023-03-01)

Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study
by: Sonja Levy, et al.
Published: (2022-05-01)

Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19
by: Naghmeh Ziaie, et al.
Published: (2023-07-01)

N-TerminalPro-B-TypeNatriuretic Peptide For Detecting Early Cardiac Dysfunction in Patients with Thyroid Dysfunction
by: Makbule Ulusoy, et al.
Published: (2013-09-01)

Changes in Cardiac Levels of Caspase-8, Bcl-2 and NT-proBNP Following 4 Weeks of Aerobic Exercise in Diabetic Rats
by: Saeid Tanoorsaz, et al.
Published: (2017-12-01)

NT-proBNP as predictor of major cardiac events after renal transplantation in patients with preserved left ventricular ejection fraction
by: Sebastian Schwab, et al.
Published: (2023-02-01)

Atrial Fibrillation, thromboembolic risk, and the potential role of the natriuretic peptides, a focus on BNP and NT-proBNP – A narrative review
by: Brian Kerr, et al.
Published: (2022-12-01)

Serum Pro‐N‐Cadherin Is a Marker of Subclinical Heart Failure in the General Population
by: Paul Durham Ferrell, et al.
Published: (2023-03-01)

Six-Month Predictive Value of Diuretic Resistance Formulas in Discharged Heart Failure Patients after an Acute Decompensation
by: Mauro Feola, et al.
Published: (2020-09-01)

Significance of NT-proBNP and High-Sensitivity Troponin in Friedreich Ataxia
by: Lise Legrand, et al.
Published: (2020-05-01)

Differences According to Age in the Diagnostic Performance of Cardiac Biomarkers to Predict Frailty in Patients with Acute Heart Failure
by: Lara Aguilar-Iglesias, et al.
Published: (2022-02-01)

Low-Level Elevations of Procalcitonin Are Associated with Increased Mortality in Acute Heart Failure Patients, Independent of Concomitant Infection
by: Fabrice F. Darche, et al.
Published: (2021-12-01)

NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis
by: Evangelos Christou, et al.
Published: (2022-06-01)

Heart failure with preserved ejection fraction in haemodialysis patients: prevalence, diagnosis, risk factors, prognosis
by: Xixi Yu, et al.
Published: (2023-10-01)

Longitudinal association between N-terminal B-type natriuretic peptide, anxiety and social support in patients with HFpEF: results from the multicentre randomized controlled Aldo-DHF trial
by: Marieke R. Wilke, et al.
Published: (2023-04-01)

N‐Terminal pro‐B‐type natriuretic peptide and stroke risk across a spectrum of cerebrovascular disease: The REasons for Geographic and Racial Differences in Stroke cohort
by: Kara K. Landry, et al.
Published: (2020-07-01)

Predictive values of clinical data,molecular biomarkers, and echocardiographic measurements in preterm infants with bronchopulmonary dysplasia
by: Huawei Wang, et al.
Published: (2023-02-01)

Development of a Rapid Diagnostic Kit for Congestive Heart Failure Using Recombinant NT-proBNP Antigen
by: Young-Ki Lee, et al.
Published: (2021-07-01)

B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors: Which One Is the Best Performer?
by: Renato de Falco, et al.
Published: (2021-06-01)

MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation
by: Luis M. Blanco-Colio, et al.
Published: (2021-03-01)

Role of NT-proBNP and lung ultrasound in diagnosing and classifying heart failure in a hospitalized oldest-old population: a cross-sectional study
by: Matteo Landolfo, et al.
Published: (2024-04-01)

A Comparative Analysis of NT-proBNP Levels in Pregnant Women and the Impact of SARS-CoV-2 Infection: Influence on Birth Outcome
by: Carmen-Ioana Marta, et al.
Published: (2023-12-01)

Mediterranean Diet, Vitamin D, and Hypercaloric, Hyperproteic Oral Supplements for Treating Sarcopenia in Patients with Heart Failure—A Randomized Clinical Trial
by: Aura D. Herrera-Martínez, et al.
Published: (2023-12-01)

Association of Paraoxonase-1 and NT-proBNP with Clinical, Clinico-Pathologic and Echocardiographic Variables in Dogs with Mitral Valve Disease
by: Diana Rammal, et al.
Published: (2023-01-01)

miR−21 and NT-proBNP Correlate with Echocardiographic Parameters of Atrial Dysfunction and Predict Atrial Fibrillation
by: Jan-Thorben Sieweke, et al.
Published: (2020-04-01)

Prognostic Significance of the N-Terminal Pro-B-Type Natriuretic Peptide in Lung Transplant Candidates on the Waiting List
by: Shimon Izhakian, et al.
Published: (2022-08-01)

Incidence and clinical/laboratory correlates of early hypotension in takotsubo syndrome
by: Gao Jing Ong, et al.
Published: (2021-06-01)

Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective
by: Nagib Dahdah, et al.
Published: (2013-01-01)

Prognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS-
by: Akira Suda, et al.
Published: (2022-12-01)

Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease
by: Jenny Wilshaw, et al.
Published: (2021-03-01)

Cardiovascular abnormalities in dogs with acute pancreatitis
by: Harry Cridge, et al.
Published: (2023-01-01)

Prognostic superiority of global longitudinal strain beyond four-tiered ventricular hypertrophy in asymptomatic individuals
by: Kuo-Tzu Sung, et al.
Published: (2022-08-01)

Prognosis Implication of N-Terminal Pro-B-Type Natriuretic Peptide in Adult Patients With Acute Myocarditis
by: Yan Zhao, et al.
Published: (2022-03-01)

Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis
by: Chengyang Xu, et al.
Published: (2020-03-01)

The role of exercise training on cardiovascular peptides in patients with heart failure: A systematic review and meta-analysis
by: Abbas Malandish, et al.
Published: (2022-01-01)