The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus
Fang Wang, Yuan-Yuan Bao, Kang Yu Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People’s Republic of ChinaCorrespondence: Kang Yu, Department of Clinical Nutrition, Peking...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-association-of-the-triglyceride-and-muscle-to-fat-ratio-during-ear-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797659059351977984 |
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| author | Wang F Bao YY Yu K |
| author_facet | Wang F Bao YY Yu K |
| author_sort | Wang F |
| collection | DOAJ |
| description | Fang Wang, Yuan-Yuan Bao, Kang Yu Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People’s Republic of ChinaCorrespondence: Kang Yu, Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Dongdansantiao, Dongcheng District, Beijing, People’s Republic of China, Tel +861169155550, Email yuk1997@sina.comObjective: This study explored the association between metabolic factors and body composition during the first trimester of gestational diabetes mellitus (GDM).Methods: This prospective study recruited pregnant women in their first trimester. Clinical information and glucose and lipid measurements were collected, and body composition was assessed using multifrequency bioelectrical impedance analysis. GDM was diagnosed on the basis of an oral glucose tolerance test at 24– 28 gestational week. Factors related to GDM were investigated using correlation, and risk ratios (RRs) and 95% CIs of potential risk factors with GDM were estimated using Poisson regression. The area under the receiver operating characteristic (ROC) curve was used to determine predictive effects.Results: 59/302 women (19.5%) developed GDM. Older (RR 1.076, 95% CI 1.005– 1.152), higher body mass index (BMI) before pregnancy (pre-BMI) (RR 1.012, 95% CI 1.005– 1.063), triglycerides (RR 4.052, 95% CI 1.641– 6.741), and lower skeletal muscle mass (SMM) to fat mass (FM) ratio (SMM/FM) (RR 0.213, 95% CI 0.051– 0890) in the first trimester, and family history of type 2 diabetes (RR 1.496, 95% CI 1.014– 2.667) significantly associated with the risk of GDM, but neither fasting plasma glucose nor glycated albumin was associated with GDM. The combined multivariate prediction model achieved good discrimination with an AUC of 0.806 (95% CI 0.737– 0.895, P< 0.001). According to ROC curve, the cut-off values of TG and SMM/FM were 0.925 mmol/L and 1.305.Conclusion: Reduced SMM/FM and elevated triglyceride (TG) levels in the first trimester are associated with GDM development, and should be screened in early pregnancy to identify high-risk subjects for GDM.Keywords: Gestational diabetes mellitus, ratio of muscle to fat, maternal triglyceride |
| first_indexed | 2024-03-11T18:08:27Z |
| format | Article |
| id | doaj.art-9b4fdb75657341e0bfd09735b192783d |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-11T18:08:27Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-9b4fdb75657341e0bfd09735b192783d2023-10-17T02:37:55ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-10-01Volume 163187319687387The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes MellitusWang FBao YYYu KFang Wang, Yuan-Yuan Bao, Kang Yu Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People’s Republic of ChinaCorrespondence: Kang Yu, Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Dongdansantiao, Dongcheng District, Beijing, People’s Republic of China, Tel +861169155550, Email yuk1997@sina.comObjective: This study explored the association between metabolic factors and body composition during the first trimester of gestational diabetes mellitus (GDM).Methods: This prospective study recruited pregnant women in their first trimester. Clinical information and glucose and lipid measurements were collected, and body composition was assessed using multifrequency bioelectrical impedance analysis. GDM was diagnosed on the basis of an oral glucose tolerance test at 24– 28 gestational week. Factors related to GDM were investigated using correlation, and risk ratios (RRs) and 95% CIs of potential risk factors with GDM were estimated using Poisson regression. The area under the receiver operating characteristic (ROC) curve was used to determine predictive effects.Results: 59/302 women (19.5%) developed GDM. Older (RR 1.076, 95% CI 1.005– 1.152), higher body mass index (BMI) before pregnancy (pre-BMI) (RR 1.012, 95% CI 1.005– 1.063), triglycerides (RR 4.052, 95% CI 1.641– 6.741), and lower skeletal muscle mass (SMM) to fat mass (FM) ratio (SMM/FM) (RR 0.213, 95% CI 0.051– 0890) in the first trimester, and family history of type 2 diabetes (RR 1.496, 95% CI 1.014– 2.667) significantly associated with the risk of GDM, but neither fasting plasma glucose nor glycated albumin was associated with GDM. The combined multivariate prediction model achieved good discrimination with an AUC of 0.806 (95% CI 0.737– 0.895, P< 0.001). According to ROC curve, the cut-off values of TG and SMM/FM were 0.925 mmol/L and 1.305.Conclusion: Reduced SMM/FM and elevated triglyceride (TG) levels in the first trimester are associated with GDM development, and should be screened in early pregnancy to identify high-risk subjects for GDM.Keywords: Gestational diabetes mellitus, ratio of muscle to fat, maternal triglyceridehttps://www.dovepress.com/the-association-of-the-triglyceride-and-muscle-to-fat-ratio-during-ear-peer-reviewed-fulltext-article-DMSOgestational diabetes mellitusratio of muscle to fatmaternal triglyceride |
| spellingShingle | Wang F Bao YY Yu K The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity gestational diabetes mellitus ratio of muscle to fat maternal triglyceride |
| title | The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus |
| title_full | The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus |
| title_fullStr | The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus |
| title_full_unstemmed | The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus |
| title_short | The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus |
| title_sort | association of the triglyceride and muscle to fat ratio during early pregnancy with the development of gestational diabetes mellitus |
| topic | gestational diabetes mellitus ratio of muscle to fat maternal triglyceride |
| url | https://www.dovepress.com/the-association-of-the-triglyceride-and-muscle-to-fat-ratio-during-ear-peer-reviewed-fulltext-article-DMSO |
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