Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

Summary Topoisomerase IIbeta (Top2b) is an enzyme that modulates DNA supercoiling by catalyzing the passage of DNA duplexes through one another. It is ubiquitously expressed in postmitotic cells and known to function during the development of neuromuscular junctions in the diaphragm and the proper f...

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Bibliographic Details
Main Authors: Ying Li, Hailing Hao, Evangeline Tzatzalos, Ren-Kuo Lin, Sungtae Doh, Leroy F. Liu, Yi Lisa Lyu, Li Cai
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Biology Open
Subjects:
Cell survival
Gene regulation
Postmitotic cells
Retina
Top2b
Transcription
Retina degeneration
Online Access:http://bio.biologists.org/content/3/2/172

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