Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility
Summary: The canine transmissible venereal tumor (CTVT) is a clonal cell-mediated cancer with a long evolutionary history and extensive karyotype rearrangements in its genome. However, little is known about its genetic similarity to human tumors. Here, using multi-omics data we identified 11 germlin...
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| Language: | English |
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Elsevier
2023-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223025087 |
| _version_ | 1797388756154580992 |
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| author | Bo-Wen Zhou Qing-Qin Wu David H. Mauki Xuan Wang Shu-Run Zhang Ting-Ting Yin Fang-Liang Chen Chao Li Yan-Hu Liu Guo-Dong Wang Ya-Ping Zhang |
| author_facet | Bo-Wen Zhou Qing-Qin Wu David H. Mauki Xuan Wang Shu-Run Zhang Ting-Ting Yin Fang-Liang Chen Chao Li Yan-Hu Liu Guo-Dong Wang Ya-Ping Zhang |
| author_sort | Bo-Wen Zhou |
| collection | DOAJ |
| description | Summary: The canine transmissible venereal tumor (CTVT) is a clonal cell-mediated cancer with a long evolutionary history and extensive karyotype rearrangements in its genome. However, little is known about its genetic similarity to human tumors. Here, using multi-omics data we identified 11 germline gene fusions (GGFs) in CTVT, which showed higher genetic susceptibility than others. Additionally, we illustrate a mechanism of a complex gene fusion of three gene segments (HSD17B4-DMXL1-TNFAIP8) that we refer to “greedy fusion”. Our findings also provided evidence that expressions of GGFs are downregulated during the tumor regressive phase, which is associated with DNA methylation level. This study presents a comprehensive landscape of gene fusions (GFs) in CTVT, which offers a valuable genetic resource for exploring potential genetic mechanisms underlying the development of cancers in both dogs and humans. |
| first_indexed | 2024-03-08T22:45:25Z |
| format | Article |
| id | doaj.art-9b54865f902d4534abe3bddfbafc5a29 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T22:45:25Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9b54865f902d4534abe3bddfbafc5a292023-12-17T06:40:46ZengElsevieriScience2589-00422023-12-012612108431Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibilityBo-Wen Zhou0Qing-Qin Wu1David H. Mauki2Xuan Wang3Shu-Run Zhang4Ting-Ting Yin5Fang-Liang Chen6Chao Li7Yan-Hu Liu8Guo-Dong Wang9Ya-Ping Zhang10State Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, ChinaSchool of Ecology and Environmental Sciences, Yunnan University, Kunming, Yunnan 650500, ChinaInstitute of Neurological Disease, National-Local Joint Engineering Research Center of Translational Medicine, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, ChinaState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, ChinaState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, ChinaKunming Police Dog Base of the Ministry of Public Security, Kunming, Yunnan 650204, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming, Yunnan 650500, ChinaState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Corresponding authorState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China; Corresponding authorState Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China; Corresponding authorSummary: The canine transmissible venereal tumor (CTVT) is a clonal cell-mediated cancer with a long evolutionary history and extensive karyotype rearrangements in its genome. However, little is known about its genetic similarity to human tumors. Here, using multi-omics data we identified 11 germline gene fusions (GGFs) in CTVT, which showed higher genetic susceptibility than others. Additionally, we illustrate a mechanism of a complex gene fusion of three gene segments (HSD17B4-DMXL1-TNFAIP8) that we refer to “greedy fusion”. Our findings also provided evidence that expressions of GGFs are downregulated during the tumor regressive phase, which is associated with DNA methylation level. This study presents a comprehensive landscape of gene fusions (GFs) in CTVT, which offers a valuable genetic resource for exploring potential genetic mechanisms underlying the development of cancers in both dogs and humans.http://www.sciencedirect.com/science/article/pii/S2589004223025087Biological sciencesGeneticsCancer systems biology |
| spellingShingle | Bo-Wen Zhou Qing-Qin Wu David H. Mauki Xuan Wang Shu-Run Zhang Ting-Ting Yin Fang-Liang Chen Chao Li Yan-Hu Liu Guo-Dong Wang Ya-Ping Zhang Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility iScience Biological sciences Genetics Cancer systems biology |
| title | Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| title_full | Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| title_fullStr | Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| title_full_unstemmed | Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| title_short | Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| title_sort | germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility |
| topic | Biological sciences Genetics Cancer systems biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223025087 |
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