Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training
Excessive training may limit physiological muscle adaptation through chronic oxidative stress and inflammation. Improper diet and overtraining may also disrupt intestinal homeostasis and in consequence enhance inflammation. Altogether, these factors may lead to an imbalance in the gut ecosystem, cau...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1451 |
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| author | Katarzyna Przewłócka Marcin Folwarski Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jan Jacek Kaczor |
| author_facet | Katarzyna Przewłócka Marcin Folwarski Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jan Jacek Kaczor |
| author_sort | Katarzyna Przewłócka |
| collection | DOAJ |
| description | Excessive training may limit physiological muscle adaptation through chronic oxidative stress and inflammation. Improper diet and overtraining may also disrupt intestinal homeostasis and in consequence enhance inflammation. Altogether, these factors may lead to an imbalance in the gut ecosystem, causing dysregulation of the immune system. Therefore, it seems to be important to optimize the intestinal microbiota composition, which is able to modulate the immune system and reduce oxidative stress. Moreover, the optimal intestinal microbiota composition may have an impact on muscle protein synthesis and mitochondrial biogenesis and function, as well as muscle glycogen storage. Aproperly balanced microbiome may also reduce inflammatory markers and reactive oxygen species production, which may further attenuate macromolecules damage. Consequently, supplementation with probiotics may have some beneficial effect on aerobic and anaerobic performance. The phenomenon of gut-muscle axis should be continuously explored to function maintenance, not only in athletes. |
| first_indexed | 2024-03-10T19:46:52Z |
| format | Article |
| id | doaj.art-9b56d3a97aee459b8bfd1796dd53c6b8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:46:52Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9b56d3a97aee459b8bfd1796dd53c6b82023-11-20T00:47:24ZengMDPI AGNutrients2072-66432020-05-01125145110.3390/nu12051451Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to TrainingKatarzyna Przewłócka0Marcin Folwarski1Karolina Kaźmierczak-Siedlecka2Karolina Skonieczna-Żydecka3Jan Jacek Kaczor4Department of Bioenergetics and Physiology of Exercise, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartmentof Clinical Nutrition and Dietetics, Medical University of Gdansk, 80-210 Gdańsk, PolandDepartment of Surgical Oncology, Medical University of Gdansk, 80-210 Gdańsk, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University, 70-204 Szczecin, PolandDepartment of Bioenergetics and Physiology of Exercise, Medical University of Gdańsk, 80-210 Gdańsk, PolandExcessive training may limit physiological muscle adaptation through chronic oxidative stress and inflammation. Improper diet and overtraining may also disrupt intestinal homeostasis and in consequence enhance inflammation. Altogether, these factors may lead to an imbalance in the gut ecosystem, causing dysregulation of the immune system. Therefore, it seems to be important to optimize the intestinal microbiota composition, which is able to modulate the immune system and reduce oxidative stress. Moreover, the optimal intestinal microbiota composition may have an impact on muscle protein synthesis and mitochondrial biogenesis and function, as well as muscle glycogen storage. Aproperly balanced microbiome may also reduce inflammatory markers and reactive oxygen species production, which may further attenuate macromolecules damage. Consequently, supplementation with probiotics may have some beneficial effect on aerobic and anaerobic performance. The phenomenon of gut-muscle axis should be continuously explored to function maintenance, not only in athletes.https://www.mdpi.com/2072-6643/12/5/1451gut microbiotaathletesmuscle functionsgut-muscle axis |
| spellingShingle | Katarzyna Przewłócka Marcin Folwarski Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jan Jacek Kaczor Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training Nutrients gut microbiota athletes muscle functions gut-muscle axis |
| title | Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training |
| title_full | Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training |
| title_fullStr | Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training |
| title_full_unstemmed | Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training |
| title_short | Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training |
| title_sort | gut muscle axis exists and may affect skeletal muscle adaptation to training |
| topic | gut microbiota athletes muscle functions gut-muscle axis |
| url | https://www.mdpi.com/2072-6643/12/5/1451 |
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