Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study
Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/5/689 |
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| author | Jannik Claus Neeraj Upadhyay Angelika Maurer Julian Klein Lukas Scheef Marcel Daamen Jason Anthony Martin Rüdiger Stirnberg Alexander Radbruch Ulrike Attenberger Tony Stöcker Henning Boecker |
| author_facet | Jannik Claus Neeraj Upadhyay Angelika Maurer Julian Klein Lukas Scheef Marcel Daamen Jason Anthony Martin Rüdiger Stirnberg Alexander Radbruch Ulrike Attenberger Tony Stöcker Henning Boecker |
| author_sort | Jannik Claus |
| collection | DOAJ |
| description | Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of chronic PA on subregional OFC FC still lacks scientific understanding. Therefore, we aimed at investigating the effects of regular PA on the FC topographies of OFC subregions in healthy individuals within a longitudinal randomized controlled exercise study. Participants (age: 18–35 years) were randomly assigned to either an intervention group (IG; N = 18) or a control group (CG; N = 10). Fitness assessments, mood questionnaires, and resting state functional magnetic resonance imaging (rsfMRI) were performed four times over the duration of 6 months. Using a detailed parcellation of the OFC, we created subregional FC topography maps at each time point and applied a linear mixed model to assess the effects of regular PA. The posterior–lateral right OFC showed a group and time interaction, revealing decreased FC with the left dorsolateral prefrontal cortex in the IG, while FC in the CG increased. Group and time interaction in the anterior–lateral right OFC with the right middle frontal gyrus was driven by increased FC in the IG. The posterior–lateral left OFC showed a group and time interaction based on differential change in FC to the left postcentral gyrus and the right occipital gyrus. This study emphasized regionally distinctive FC changes induced by PA within the lateral OFC territory, while providing aspects for further research. |
| first_indexed | 2024-03-11T07:24:44Z |
| format | Article |
| id | doaj.art-9b56fe384d6d4dba90936952ad226269 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T07:24:44Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-9b56fe384d6d4dba90936952ad2262692023-11-17T07:43:14ZengMDPI AGHealthcare2227-90322023-02-0111568910.3390/healthcare11050689Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI StudyJannik Claus0Neeraj Upadhyay1Angelika Maurer2Julian Klein3Lukas Scheef4Marcel Daamen5Jason Anthony Martin6Rüdiger Stirnberg7Alexander Radbruch8Ulrike Attenberger9Tony Stöcker10Henning Boecker11Clinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases, Venusberg-Campus 1, Building 99, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases, Venusberg-Campus 1, Building 99, 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases, Venusberg-Campus 1, Building 99, 53127 Bonn, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases, Venusberg-Campus 1, Building 99, 53127 Bonn, GermanyClinical Functional Imaging Lab, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyPhysical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of chronic PA on subregional OFC FC still lacks scientific understanding. Therefore, we aimed at investigating the effects of regular PA on the FC topographies of OFC subregions in healthy individuals within a longitudinal randomized controlled exercise study. Participants (age: 18–35 years) were randomly assigned to either an intervention group (IG; N = 18) or a control group (CG; N = 10). Fitness assessments, mood questionnaires, and resting state functional magnetic resonance imaging (rsfMRI) were performed four times over the duration of 6 months. Using a detailed parcellation of the OFC, we created subregional FC topography maps at each time point and applied a linear mixed model to assess the effects of regular PA. The posterior–lateral right OFC showed a group and time interaction, revealing decreased FC with the left dorsolateral prefrontal cortex in the IG, while FC in the CG increased. Group and time interaction in the anterior–lateral right OFC with the right middle frontal gyrus was driven by increased FC in the IG. The posterior–lateral left OFC showed a group and time interaction based on differential change in FC to the left postcentral gyrus and the right occipital gyrus. This study emphasized regionally distinctive FC changes induced by PA within the lateral OFC territory, while providing aspects for further research.https://www.mdpi.com/2227-9032/11/5/689exercisefunctional connectivitymoodorbitofrontal cortexphysical activityrsfMRI |
| spellingShingle | Jannik Claus Neeraj Upadhyay Angelika Maurer Julian Klein Lukas Scheef Marcel Daamen Jason Anthony Martin Rüdiger Stirnberg Alexander Radbruch Ulrike Attenberger Tony Stöcker Henning Boecker Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study Healthcare exercise functional connectivity mood orbitofrontal cortex physical activity rsfMRI |
| title | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
| title_full | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
| title_fullStr | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
| title_full_unstemmed | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
| title_short | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
| title_sort | physical activity alters functional connectivity of orbitofrontal cortex subdivisions in healthy young adults a longitudinal fmri study |
| topic | exercise functional connectivity mood orbitofrontal cortex physical activity rsfMRI |
| url | https://www.mdpi.com/2227-9032/11/5/689 |
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