Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions
Abstract Background We propose a comprehensive evaluation of a Discovery MI 4-ring (DMI) model, using a Monte Carlo simulator (GATE) and a clinical reconstruction software package (PET toolbox). The following performance characteristics were compared with actual measurements according to NEMA NU 2-2...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-024-00616-4 |
| _version_ | 1797273187044556800 |
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| author | Antoine Merlet Benoît Presles Kuan-Hao Su Julien Salvadori Farzam Sayah Hanieh Jozi Alexandre Cochet Jean-Marc Vrigneaud |
| author_facet | Antoine Merlet Benoît Presles Kuan-Hao Su Julien Salvadori Farzam Sayah Hanieh Jozi Alexandre Cochet Jean-Marc Vrigneaud |
| author_sort | Antoine Merlet |
| collection | DOAJ |
| description | Abstract Background We propose a comprehensive evaluation of a Discovery MI 4-ring (DMI) model, using a Monte Carlo simulator (GATE) and a clinical reconstruction software package (PET toolbox). The following performance characteristics were compared with actual measurements according to NEMA NU 2-2018 guidelines: system sensitivity, count losses and scatter fraction (SF), coincidence time resolution (CTR), spatial resolution (SR), and image quality (IQ). For SR and IQ tests, reconstruction of time-of-flight (TOF) simulated data was performed using the manufacturer’s reconstruction software. Results Simulated prompt, random, true, scatter and noise equivalent count rates closely matched the experimental rates with maximum relative differences of 1.6%, 5.3%, 7.8%, 6.6%, and 16.5%, respectively, in a clinical range of less than 10 kBq/mL. A 3.6% maximum relative difference was found between experimental and simulated sensitivities. The simulated spatial resolution was better than the experimental one. Simulated image quality metrics were relatively close to the experimental results. Conclusions The current model is able to reproduce the behaviour of the DMI count rates in the clinical range and generate clinical-like images with a reasonable match in terms of contrast and noise. |
| first_indexed | 2024-03-07T14:39:57Z |
| format | Article |
| id | doaj.art-9b575e49e2044612a5457d3309caadd6 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-03-07T14:39:57Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-9b575e49e2044612a5457d3309caadd62024-03-05T20:24:17ZengSpringerOpenEJNMMI Physics2197-73642024-01-0111112310.1186/s40658-024-00616-4Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructionsAntoine Merlet0Benoît Presles1Kuan-Hao Su2Julien Salvadori3Farzam Sayah4Hanieh Jozi5Alexandre Cochet6Jean-Marc Vrigneaud7Imagerie et Vision artificielle, ImViA EA 7535, University of BurgundyInstitut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), UMR CNRS 6302, University of BurgundyGE HealthcareICANS, Institut de cancérologie Strasbourg EuropeDepartment of Nuclear Medicine, Georges-François Leclerc Cancer CentreDepartment of Nuclear Medicine, Georges-François Leclerc Cancer CentreInstitut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), UMR CNRS 6302, University of BurgundyInstitut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), UMR CNRS 6302, University of BurgundyAbstract Background We propose a comprehensive evaluation of a Discovery MI 4-ring (DMI) model, using a Monte Carlo simulator (GATE) and a clinical reconstruction software package (PET toolbox). The following performance characteristics were compared with actual measurements according to NEMA NU 2-2018 guidelines: system sensitivity, count losses and scatter fraction (SF), coincidence time resolution (CTR), spatial resolution (SR), and image quality (IQ). For SR and IQ tests, reconstruction of time-of-flight (TOF) simulated data was performed using the manufacturer’s reconstruction software. Results Simulated prompt, random, true, scatter and noise equivalent count rates closely matched the experimental rates with maximum relative differences of 1.6%, 5.3%, 7.8%, 6.6%, and 16.5%, respectively, in a clinical range of less than 10 kBq/mL. A 3.6% maximum relative difference was found between experimental and simulated sensitivities. The simulated spatial resolution was better than the experimental one. Simulated image quality metrics were relatively close to the experimental results. Conclusions The current model is able to reproduce the behaviour of the DMI count rates in the clinical range and generate clinical-like images with a reasonable match in terms of contrast and noise.https://doi.org/10.1186/s40658-024-00616-4PETNuclear medicineGATEMonte Carlo simulationNEMA |
| spellingShingle | Antoine Merlet Benoît Presles Kuan-Hao Su Julien Salvadori Farzam Sayah Hanieh Jozi Alexandre Cochet Jean-Marc Vrigneaud Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions EJNMMI Physics PET Nuclear medicine GATE Monte Carlo simulation NEMA |
| title | Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions |
| title_full | Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions |
| title_fullStr | Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions |
| title_full_unstemmed | Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions |
| title_short | Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions |
| title_sort | validation of a discovery mi 4 ring model according to the nema nu 2 2018 standards from monte carlo simulations to clinical like reconstructions |
| topic | PET Nuclear medicine GATE Monte Carlo simulation NEMA |
| url | https://doi.org/10.1186/s40658-024-00616-4 |
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