A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries
Genetic variations in the human genome represent the differences in DNA sequence within individuals. This highlights the important role of whole human genome sequencing which has become the keystone for precision medicine and disease prediction. Morocco is an important hub for studying human populat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-02-01
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| Series: | Evolutionary Bioinformatics |
| Online Access: | https://doi.org/10.1177/11769343241229278 |
| _version_ | 1797321648799481856 |
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| author | Nasma Boumajdi Houda Bendani Souad Kartti Tarek Alouane Lahcen Belyamani Azeddine Ibrahimi |
| author_facet | Nasma Boumajdi Houda Bendani Souad Kartti Tarek Alouane Lahcen Belyamani Azeddine Ibrahimi |
| author_sort | Nasma Boumajdi |
| collection | DOAJ |
| description | Genetic variations in the human genome represent the differences in DNA sequence within individuals. This highlights the important role of whole human genome sequencing which has become the keystone for precision medicine and disease prediction. Morocco is an important hub for studying human population migration and mixing history. This study presents the analysis of 3 Moroccan genomes; the variant analysis revealed 6 379 606 single nucleotide variants (SNVs) and 1 050 577 small InDels. Of those identified SNVs, 219 152 were novel, with 1233 occurring in coding regions, and 5580 non-synonymous single nucleotide variants (nsSNP) variants were predicted to affect protein functions. The InDels produced 1055 coding variants and 454 non-3n length variants, and their size ranged from -49 and 49 bp. We further analysed the gene pathways of 8 novel coding variants found in the 3 genomes and revealed 5 genes involved in various diseases and biological pathways. We found that the Moroccan genomes share 92.78% of African ancestry, and 92.86% of Non-Finnish European ancestry, according to the gnomAD database. Then, population structure inference, by admixture analysis and network-based approach, revealed that the studied genomes form a mixed population structure, highlighting the increased genetic diversity in Morocco. |
| first_indexed | 2024-03-08T05:02:36Z |
| format | Article |
| id | doaj.art-9b576eb867294731bcfc8cd2ce5e2ef1 |
| institution | Directory Open Access Journal |
| issn | 1176-9343 |
| language | English |
| last_indexed | 2024-03-08T05:02:36Z |
| publishDate | 2024-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Evolutionary Bioinformatics |
| spelling | doaj.art-9b576eb867294731bcfc8cd2ce5e2ef12024-02-07T11:04:09ZengSAGE PublishingEvolutionary Bioinformatics1176-93432024-02-012010.1177/11769343241229278A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European AncestriesNasma Boumajdi0Houda Bendani1Souad Kartti2Tarek Alouane3Lahcen Belyamani4Azeddine Ibrahimi5Mohammed VI Center for Research & Innovation (CM6), Rabat, MoroccoMohammed VI Center for Research & Innovation (CM6), Rabat, MoroccoMohammed VI Center for Research & Innovation (CM6), Rabat, MoroccoLaboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, MoroccoEmergency Department, Military Hospital Mohammed V, Rabat Medical and Pharmacy School, Mohammed V University, Rabat, MoroccoMohammed VI University of Health Sciences (UM6SS), Casablanca, MoroccoGenetic variations in the human genome represent the differences in DNA sequence within individuals. This highlights the important role of whole human genome sequencing which has become the keystone for precision medicine and disease prediction. Morocco is an important hub for studying human population migration and mixing history. This study presents the analysis of 3 Moroccan genomes; the variant analysis revealed 6 379 606 single nucleotide variants (SNVs) and 1 050 577 small InDels. Of those identified SNVs, 219 152 were novel, with 1233 occurring in coding regions, and 5580 non-synonymous single nucleotide variants (nsSNP) variants were predicted to affect protein functions. The InDels produced 1055 coding variants and 454 non-3n length variants, and their size ranged from -49 and 49 bp. We further analysed the gene pathways of 8 novel coding variants found in the 3 genomes and revealed 5 genes involved in various diseases and biological pathways. We found that the Moroccan genomes share 92.78% of African ancestry, and 92.86% of Non-Finnish European ancestry, according to the gnomAD database. Then, population structure inference, by admixture analysis and network-based approach, revealed that the studied genomes form a mixed population structure, highlighting the increased genetic diversity in Morocco.https://doi.org/10.1177/11769343241229278 |
| spellingShingle | Nasma Boumajdi Houda Bendani Souad Kartti Tarek Alouane Lahcen Belyamani Azeddine Ibrahimi A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries Evolutionary Bioinformatics |
| title | A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries |
| title_full | A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries |
| title_fullStr | A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries |
| title_full_unstemmed | A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries |
| title_short | A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries |
| title_sort | comprehensive analysis of 3 moroccan genomes revealed contributions from both african and european ancestries |
| url | https://doi.org/10.1177/11769343241229278 |
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