Enhancer RNAs in transcriptional regulation: recent insights
Enhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse contexts, referred to as enhancer RNAs (eRNAs). Emergin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1205540/full |
| _version_ | 1797825544860991488 |
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| author | Qi Chen Yaxin Zeng Jinjin Kang Minghui Hu Nianle Li Kun Sun Yu Zhao |
| author_facet | Qi Chen Yaxin Zeng Jinjin Kang Minghui Hu Nianle Li Kun Sun Yu Zhao |
| author_sort | Qi Chen |
| collection | DOAJ |
| description | Enhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse contexts, referred to as enhancer RNAs (eRNAs). Emerging evidence unequivocally suggests eRNAs are an important layer in transcriptional regulation. In this mini-review, we summarize the well-established regulatory models for eRNA actions and highlight the recent insights into the structure and chemical modifications of eRNAs underlying their functions. We also explore the potential roles of eRNAs in transcriptional condensates. |
| first_indexed | 2024-03-13T10:55:29Z |
| format | Article |
| id | doaj.art-9b57f57dad254bf1ba7c2469e4d2b948 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-13T10:55:29Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9b57f57dad254bf1ba7c2469e4d2b9482023-05-17T04:56:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.12055401205540Enhancer RNAs in transcriptional regulation: recent insightsQi Chen0Yaxin Zeng1Jinjin Kang2Minghui Hu3Nianle Li4Kun Sun5Yu Zhao6The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaMolecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaMolecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaMolecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaMolecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaInstitute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, ChinaMolecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaEnhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse contexts, referred to as enhancer RNAs (eRNAs). Emerging evidence unequivocally suggests eRNAs are an important layer in transcriptional regulation. In this mini-review, we summarize the well-established regulatory models for eRNA actions and highlight the recent insights into the structure and chemical modifications of eRNAs underlying their functions. We also explore the potential roles of eRNAs in transcriptional condensates.https://www.frontiersin.org/articles/10.3389/fcell.2023.1205540/fulleRNAtranscriptional regulationchromatin loopingphase separationepitranscriptome |
| spellingShingle | Qi Chen Yaxin Zeng Jinjin Kang Minghui Hu Nianle Li Kun Sun Yu Zhao Enhancer RNAs in transcriptional regulation: recent insights Frontiers in Cell and Developmental Biology eRNA transcriptional regulation chromatin looping phase separation epitranscriptome |
| title | Enhancer RNAs in transcriptional regulation: recent insights |
| title_full | Enhancer RNAs in transcriptional regulation: recent insights |
| title_fullStr | Enhancer RNAs in transcriptional regulation: recent insights |
| title_full_unstemmed | Enhancer RNAs in transcriptional regulation: recent insights |
| title_short | Enhancer RNAs in transcriptional regulation: recent insights |
| title_sort | enhancer rnas in transcriptional regulation recent insights |
| topic | eRNA transcriptional regulation chromatin looping phase separation epitranscriptome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1205540/full |
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