Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved]
Primary progressive aphasia (PPA) is classified into three variants, logopenic variant PPA (lvPPA), nonfluent agrammatic PPA (nfaPPA), and semantic variant PPA (svPPA), based on clinical (syndromic) characteristics with support from neuroimaging and/or underlying neuropathology. Classification of PP...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-64/v1 |
| _version_ | 1819023410867470336 |
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| author | Donna C. Tippett |
| author_facet | Donna C. Tippett |
| author_sort | Donna C. Tippett |
| collection | DOAJ |
| description | Primary progressive aphasia (PPA) is classified into three variants, logopenic variant PPA (lvPPA), nonfluent agrammatic PPA (nfaPPA), and semantic variant PPA (svPPA), based on clinical (syndromic) characteristics with support from neuroimaging and/or underlying neuropathology. Classification of PPA variants provides information valuable to disease management. International consensus criteria are widely employed to identify PPA subtypes; however, classification is complex, and some individuals do not fit neatly into the subtyping scheme. In this review, diagnostic challenges and their implications are discussed, possible explanations for these challenges are explored, and approaches to address PPA classification are considered. |
| first_indexed | 2024-12-21T04:38:27Z |
| format | Article |
| id | doaj.art-9b580212401241edb888f42d9ce001ed |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T04:38:27Z |
| publishDate | 2020-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-9b580212401241edb888f42d9ce001ed2022-12-21T19:15:47ZengF1000 Research LtdF1000Research2046-14022020-01-01910.12688/f1000research.21184.123319Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved]Donna C. Tippett0Departments of Neurology, Otolaryngology - Head and Neck Surgery, and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USAPrimary progressive aphasia (PPA) is classified into three variants, logopenic variant PPA (lvPPA), nonfluent agrammatic PPA (nfaPPA), and semantic variant PPA (svPPA), based on clinical (syndromic) characteristics with support from neuroimaging and/or underlying neuropathology. Classification of PPA variants provides information valuable to disease management. International consensus criteria are widely employed to identify PPA subtypes; however, classification is complex, and some individuals do not fit neatly into the subtyping scheme. In this review, diagnostic challenges and their implications are discussed, possible explanations for these challenges are explored, and approaches to address PPA classification are considered.https://f1000research.com/articles/9-64/v1 |
| spellingShingle | Donna C. Tippett Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] F1000Research |
| title | Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] |
| title_full | Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] |
| title_fullStr | Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] |
| title_full_unstemmed | Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] |
| title_short | Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved] |
| title_sort | classification of primary progressive aphasia challenges and complexities version 1 peer review 2 approved |
| url | https://f1000research.com/articles/9-64/v1 |
| work_keys_str_mv | AT donnactippett classificationofprimaryprogressiveaphasiachallengesandcomplexitiesversion1peerreview2approved |