Russian National Research Medical University named after N.I. Pirogov, Moscow
<p><strong>Aim. </strong>To identify risk factors of decompensation of chronic heart failure (CHF) and related hospitalization in elderly outpatients.</p><p><strong>Material and methods. </strong>The total of 248 patients aged 60–85 years with CHF NYHA class...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/36 |
| _version_ | 1797762534620528640 |
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| author | V. N. Larina B. Ya. Bart E. A. Vartanyan |
| author_facet | V. N. Larina B. Ya. Bart E. A. Vartanyan |
| author_sort | V. N. Larina |
| collection | DOAJ |
| description | <p><strong>Aim. </strong>To identify risk factors of decompensation of chronic heart failure (CHF) and related hospitalization in elderly outpatients.</p><p><strong>Material and methods. </strong>The total of 248 patients aged 60–85 years with CHF NYHA class II-IV were enrolled into the study. The first group consisted of 87 (35.1%) patients who required hospitalization due to CHF decompensation during the follow-up, the second group of 161 patients without need for hospital admission. All the patients had undergone clinical and laboratory examination, estimation of CHF severity by the Scale of clinical state, assessment of quality of life and 6-minute walk test (6MWT), echocardiography.</p><p><strong>Results. </strong>Patients were matched for age, gender, disability occurrence, education level, body mass index, quality of life, hemodynamic parameters, incidence rates of anemia, diabetes mellitus and atrial fibrillation. CHF was more severe in patients who had required hospitalization (p<0.001), they were more often diagnosed with left ventricular aneurysm (p=0.001), chronic kidney disease (p=0.001), left ventricular ejection fraction (LVEF)<35% (p<0.001), history of stroke (p<0.001), III-IV degree mitral regurgitation (p=0.007), hyperuricemia (p<0.001), lower exercise tolerance (p=0.007) compared with patients without hospitalization. Higher functional class of CHF (OR=0.29; 95% CI 0.13–0.69; p=0.003), LVEF<35% (OR 0.37; 95% CI 0.18–0.76; p=0.007), chronic kidney disease (OR=0.29; 95% CI 0.13–0.68; p=0.004) and hyperuricemia (OR=0.23; 95%CI 0.10–0.50; p<0.001) were shown to be independent risk factors of CHF decompensation that required hospital admission in elderly patients.</p><p><strong>Conclusuion. </strong>High FC of CHF, low LVEF, hyperuricemia and renal dysfunction play a key role in CHF decompensation and related hospitalization in elderly patients.</p> |
| first_indexed | 2024-03-12T19:28:49Z |
| format | Article |
| id | doaj.art-9b581f0e3ecd425f9eee873b7c14def5 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T19:28:49Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-9b581f0e3ecd425f9eee873b7c14def52023-08-02T04:42:51ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0191152410.1234/1819-6446-2013-1-15-2436Russian National Research Medical University named after N.I. Pirogov, MoscowV. N. Larina0B. Ya. Bart1E. A. Vartanyan2Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, МоскваРоссийский национальный исследовательский медицинский университет имени Н.И. Пирогова, МоскваРоссийский национальный исследовательский медицинский университет имени Н.И. Пирогова, Москва<p><strong>Aim. </strong>To identify risk factors of decompensation of chronic heart failure (CHF) and related hospitalization in elderly outpatients.</p><p><strong>Material and methods. </strong>The total of 248 patients aged 60–85 years with CHF NYHA class II-IV were enrolled into the study. The first group consisted of 87 (35.1%) patients who required hospitalization due to CHF decompensation during the follow-up, the second group of 161 patients without need for hospital admission. All the patients had undergone clinical and laboratory examination, estimation of CHF severity by the Scale of clinical state, assessment of quality of life and 6-minute walk test (6MWT), echocardiography.</p><p><strong>Results. </strong>Patients were matched for age, gender, disability occurrence, education level, body mass index, quality of life, hemodynamic parameters, incidence rates of anemia, diabetes mellitus and atrial fibrillation. CHF was more severe in patients who had required hospitalization (p<0.001), they were more often diagnosed with left ventricular aneurysm (p=0.001), chronic kidney disease (p=0.001), left ventricular ejection fraction (LVEF)<35% (p<0.001), history of stroke (p<0.001), III-IV degree mitral regurgitation (p=0.007), hyperuricemia (p<0.001), lower exercise tolerance (p=0.007) compared with patients without hospitalization. Higher functional class of CHF (OR=0.29; 95% CI 0.13–0.69; p=0.003), LVEF<35% (OR 0.37; 95% CI 0.18–0.76; p=0.007), chronic kidney disease (OR=0.29; 95% CI 0.13–0.68; p=0.004) and hyperuricemia (OR=0.23; 95%CI 0.10–0.50; p<0.001) were shown to be independent risk factors of CHF decompensation that required hospital admission in elderly patients.</p><p><strong>Conclusuion. </strong>High FC of CHF, low LVEF, hyperuricemia and renal dysfunction play a key role in CHF decompensation and related hospitalization in elderly patients.</p>http://www.rpcardio.ru/jour/article/view/36хроническая сердечная недостаточностьгоспитализацияпожилые больные |
| spellingShingle | V. N. Larina B. Ya. Bart E. A. Vartanyan Russian National Research Medical University named after N.I. Pirogov, Moscow Рациональная фармакотерапия в кардиологии хроническая сердечная недостаточность госпитализация пожилые больные |
| title | Russian National Research Medical University named after N.I. Pirogov, Moscow |
| title_full | Russian National Research Medical University named after N.I. Pirogov, Moscow |
| title_fullStr | Russian National Research Medical University named after N.I. Pirogov, Moscow |
| title_full_unstemmed | Russian National Research Medical University named after N.I. Pirogov, Moscow |
| title_short | Russian National Research Medical University named after N.I. Pirogov, Moscow |
| title_sort | russian national research medical university named after n i pirogov moscow |
| topic | хроническая сердечная недостаточность госпитализация пожилые больные |
| url | http://www.rpcardio.ru/jour/article/view/36 |
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