Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes
The aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospective...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/11/2600 |
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| author | Daniela Alterio Simona Marani Valeria Zurlo Stefano Filippo Zorzi Annamaria Ferrari Stefania Volpe Francesco Bandi Sabrina Vigorito Maria Giulia Vincini Sara Gandini Aurora Gaeta Cristiana Iuliana Fodor Alessia Casbarra Mattia Zaffaroni Anna Starzyńska Liliana Belgioia Mohssen Ansarin Cynthia Aristei Barbara Alicja Jereczek-Fossa |
| author_facet | Daniela Alterio Simona Marani Valeria Zurlo Stefano Filippo Zorzi Annamaria Ferrari Stefania Volpe Francesco Bandi Sabrina Vigorito Maria Giulia Vincini Sara Gandini Aurora Gaeta Cristiana Iuliana Fodor Alessia Casbarra Mattia Zaffaroni Anna Starzyńska Liliana Belgioia Mohssen Ansarin Cynthia Aristei Barbara Alicja Jereczek-Fossa |
| author_sort | Daniela Alterio |
| collection | DOAJ |
| description | The aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospectively collected. Results. In total, 20 patients were analyzed. Of these, six patients (35%) required the positioning of a temporary tracheostomy. The functional larynx preservation rate was 95%. Females had a higher risk of both endoscopic intervention and chondronecrosis, while the median age was significantly higher in patients requiring enteral nutrition. The incidence of long-term severe toxicities was lower in patients treated with IMRT than in the historical 3D-CRT cohort. Patients who had received PORT-IMRT achieved a lower rate of permanent laryngeal and swallowing dysfunctions. Overall, results from the comparison with the historical 3D-CRT cohort favor the IMRTs. |
| first_indexed | 2024-03-10T01:27:56Z |
| format | Article |
| id | doaj.art-9b5b7f1a07684cffb7d6453ef797546c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:27:56Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9b5b7f1a07684cffb7d6453ef797546c2023-11-23T13:47:58ZengMDPI AGCancers2072-66942022-05-011411260010.3390/cancers14112600Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional OutcomesDaniela Alterio0Simona Marani1Valeria Zurlo2Stefano Filippo Zorzi3Annamaria Ferrari4Stefania Volpe5Francesco Bandi6Sabrina Vigorito7Maria Giulia Vincini8Sara Gandini9Aurora Gaeta10Cristiana Iuliana Fodor11Alessia Casbarra12Mattia Zaffaroni13Anna Starzyńska14Liliana Belgioia15Mohssen Ansarin16Cynthia Aristei17Barbara Alicja Jereczek-Fossa18Division of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Otolaryngology and Head and Neck Surgery, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Otolaryngology and Head and Neck Surgery, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Otolaryngology and Head and Neck Surgery, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyUnit of Medical Physics, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Experimental Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Experimental Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Oral Surgery, Medical University of Gdańsk, 80-210 Gdańsk, PolandRadiation Oncology Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale Policlinico San Martino, 16132 Genova, ItalyDepartment of Otolaryngology and Head and Neck Surgery, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyRadiation Oncology Section, Department of Medicine and Surgery, University of Perugia and Perugia General Hospital, 06123 Perugia, ItalyDivision of Radiation Oncology, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyThe aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospectively collected. Results. In total, 20 patients were analyzed. Of these, six patients (35%) required the positioning of a temporary tracheostomy. The functional larynx preservation rate was 95%. Females had a higher risk of both endoscopic intervention and chondronecrosis, while the median age was significantly higher in patients requiring enteral nutrition. The incidence of long-term severe toxicities was lower in patients treated with IMRT than in the historical 3D-CRT cohort. Patients who had received PORT-IMRT achieved a lower rate of permanent laryngeal and swallowing dysfunctions. Overall, results from the comparison with the historical 3D-CRT cohort favor the IMRTs.https://www.mdpi.com/2072-6694/14/11/2600intensity-modulated radiotherapytoxicitysupraglottic regionorgan preservation |
| spellingShingle | Daniela Alterio Simona Marani Valeria Zurlo Stefano Filippo Zorzi Annamaria Ferrari Stefania Volpe Francesco Bandi Sabrina Vigorito Maria Giulia Vincini Sara Gandini Aurora Gaeta Cristiana Iuliana Fodor Alessia Casbarra Mattia Zaffaroni Anna Starzyńska Liliana Belgioia Mohssen Ansarin Cynthia Aristei Barbara Alicja Jereczek-Fossa Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes Cancers intensity-modulated radiotherapy toxicity supraglottic region organ preservation |
| title | Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes |
| title_full | Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes |
| title_fullStr | Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes |
| title_full_unstemmed | Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes |
| title_short | Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes |
| title_sort | intensity modulated radiotherapy imrt following conservative surgery of the supraglottic region impact on functional outcomes |
| topic | intensity-modulated radiotherapy toxicity supraglottic region organ preservation |
| url | https://www.mdpi.com/2072-6694/14/11/2600 |
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