The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults
BackgroundWe investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults.MethodsNine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Bod...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Korean Endocrine Society
2013-03-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-28-33.pdf |
| _version_ | 1818569572448468992 |
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| author | Jung-Hee Yu Seo Hyoung Yim Su Hyeon Yu Ji Yong Lee Jong Dae Kim Mi Hae Seo Won Seon Jeon Se-Eun Park Cheol-Young Park Won-Young Lee Ki-Won Oh Sung-Woo Park Eun-Jung Rhee |
| author_facet | Jung-Hee Yu Seo Hyoung Yim Su Hyeon Yu Ji Yong Lee Jong Dae Kim Mi Hae Seo Won Seon Jeon Se-Eun Park Cheol-Young Park Won-Young Lee Ki-Won Oh Sung-Woo Park Eun-Jung Rhee |
| author_sort | Jung-Hee Yu |
| collection | DOAJ |
| description | BackgroundWe investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults.MethodsNine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography.ResultsOne hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women).ConclusionIn our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis. |
| first_indexed | 2024-12-14T06:49:45Z |
| format | Article |
| id | doaj.art-9b5c45ad6a674a00be8132c1f1140c4c |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-14T06:49:45Z |
| publishDate | 2013-03-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-9b5c45ad6a674a00be8132c1f1140c4c2022-12-21T23:12:55ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782013-03-01281334010.3803/EnM.2013.28.1.3321963The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean AdultsJung-Hee YuSeo Hyoung YimSu Hyeon YuJi Yong LeeJong Dae KimMi Hae SeoWon Seon JeonSe-Eun ParkCheol-Young ParkWon-Young LeeKi-Won OhSung-Woo ParkEun-Jung RheeBackgroundWe investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults.MethodsNine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography.ResultsOne hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women).ConclusionIn our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-28-33.pdfCoronary artery calcium scoreWaist-hip ratioObesity, abdominal |
| spellingShingle | Jung-Hee Yu Seo Hyoung Yim Su Hyeon Yu Ji Yong Lee Jong Dae Kim Mi Hae Seo Won Seon Jeon Se-Eun Park Cheol-Young Park Won-Young Lee Ki-Won Oh Sung-Woo Park Eun-Jung Rhee The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults Endocrinology and Metabolism Coronary artery calcium score Waist-hip ratio Obesity, abdominal |
| title | The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults |
| title_full | The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults |
| title_fullStr | The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults |
| title_full_unstemmed | The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults |
| title_short | The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults |
| title_sort | relationship of body composition and coronary artery calcification in apparently healthy korean adults |
| topic | Coronary artery calcium score Waist-hip ratio Obesity, abdominal |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-28-33.pdf |
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