Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy
Mutations in genes encoding chromatin regulators are early events contributing to developing asymptomatic clonal hematopoiesis of indeterminate potential and its frequent progression to myeloid diseases with increasing severity. We focus on the subset of myeloid diseases encompassing myelodysplastic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/7/1746 |
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| author | Michael Maher Jeannine Diesch Marguerite-Marie Le Pannérer Marcus Buschbeck |
| author_facet | Michael Maher Jeannine Diesch Marguerite-Marie Le Pannérer Marcus Buschbeck |
| author_sort | Michael Maher |
| collection | DOAJ |
| description | Mutations in genes encoding chromatin regulators are early events contributing to developing asymptomatic clonal hematopoiesis of indeterminate potential and its frequent progression to myeloid diseases with increasing severity. We focus on the subset of myeloid diseases encompassing myelodysplastic syndromes and their transformation to secondary acute myeloid leukemia. We introduce the major concepts of chromatin regulation that provide the basis of epigenetic regulation. In greater detail, we discuss those chromatin regulators that are frequently mutated in myelodysplastic syndromes. We discuss their role in the epigenetic regulation of normal hematopoiesis and the consequence of their mutation. Finally, we provide an update on the drugs interfering with chromatin regulation approved or in development for myelodysplastic syndromes and acute myeloid leukemia. |
| first_indexed | 2024-03-10T12:34:02Z |
| format | Article |
| id | doaj.art-9b5d62ee18ae4cec9120a931ae33f594 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:34:02Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9b5d62ee18ae4cec9120a931ae33f5942023-11-21T14:24:16ZengMDPI AGCancers2072-66942021-04-01137174610.3390/cancers13071746Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for TherapyMichael Maher0Jeannine Diesch1Marguerite-Marie Le Pannérer2Marcus Buschbeck3Cancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, 08916 Badalona, SpainCancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, 08916 Badalona, SpainCancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, 08916 Badalona, SpainCancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, 08916 Badalona, SpainMutations in genes encoding chromatin regulators are early events contributing to developing asymptomatic clonal hematopoiesis of indeterminate potential and its frequent progression to myeloid diseases with increasing severity. We focus on the subset of myeloid diseases encompassing myelodysplastic syndromes and their transformation to secondary acute myeloid leukemia. We introduce the major concepts of chromatin regulation that provide the basis of epigenetic regulation. In greater detail, we discuss those chromatin regulators that are frequently mutated in myelodysplastic syndromes. We discuss their role in the epigenetic regulation of normal hematopoiesis and the consequence of their mutation. Finally, we provide an update on the drugs interfering with chromatin regulation approved or in development for myelodysplastic syndromes and acute myeloid leukemia.https://www.mdpi.com/2072-6694/13/7/1746epigeneticschromatinepigenetic regulatorsclonal hematopoiesis of indeterminate potential (CHIP)myelodysplastic syndromes (MDS)acute myeloid leukemia (AML) |
| spellingShingle | Michael Maher Jeannine Diesch Marguerite-Marie Le Pannérer Marcus Buschbeck Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy Cancers epigenetics chromatin epigenetic regulators clonal hematopoiesis of indeterminate potential (CHIP) myelodysplastic syndromes (MDS) acute myeloid leukemia (AML) |
| title | Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy |
| title_full | Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy |
| title_fullStr | Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy |
| title_full_unstemmed | Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy |
| title_short | Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy |
| title_sort | epigenetics in a spectrum of myeloid diseases and its exploitation for therapy |
| topic | epigenetics chromatin epigenetic regulators clonal hematopoiesis of indeterminate potential (CHIP) myelodysplastic syndromes (MDS) acute myeloid leukemia (AML) |
| url | https://www.mdpi.com/2072-6694/13/7/1746 |
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