Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage
Pancreatic leakage is severe and life-threatening when happening pancreatitis or conducting pancreatectomy on patients, which easily induces bleeding, infection and even death. Commercial tissue adhesives cannot meet the demands for pancreatic leakage sealing due to the weak adhesiveness, potential...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522009030 |
| _version_ | 1797980236270272512 |
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| author | Zhenyu Yang Xueqiao Yu Pengfei Wei Yiqian Huang Shuai Zhou Wei Jing Yan Zhang Liya Sun Guoqiang Bao Xianli He Bo Zhao |
| author_facet | Zhenyu Yang Xueqiao Yu Pengfei Wei Yiqian Huang Shuai Zhou Wei Jing Yan Zhang Liya Sun Guoqiang Bao Xianli He Bo Zhao |
| author_sort | Zhenyu Yang |
| collection | DOAJ |
| description | Pancreatic leakage is severe and life-threatening when happening pancreatitis or conducting pancreatectomy on patients, which easily induces bleeding, infection and even death. Commercial tissue adhesives cannot meet the demands for pancreatic leakage sealing due to the weak adhesiveness, potential toxicity and inability to degrade. Few reports have been feasibly paid attention to pancreas sealants due to the complicated conditions such as enzymatic microenvironments, mechanical dynamics and pre-infections. Herein, we prepared a rapid high-adhesion, antibacterial, biodegradable and injectable bioadhesive based on the FDA-approved polyethylene glycol to seal the pancreatic leakage for clinical translations and commercial applications. The tetra-armed poly(ethylene glycol) succinimidyl glutarate (PEG-SG), tetra-armed poly(ethylene glycol) amine (PEG-NH2) and tannic acid (TA) were integrated to rapidly form the adhesive hydrogel (gelling time < 5 seconds) for convenient operations, while this bioadhesive achieved tough tissue adhesion (∼ 30 kPa), robust antibacterial activity (∼ 95% efficiency) and biocompatibility, revealing the excellent performances for pancreatic wound closure. In the established pre-clinical pancreatectomy using Bama miniature pig model, the bioadhesive presented efficient outcomes on pancreatic leakage, and this indicated the promising feasibility of the bioadhesive for clinical trials and translations. |
| first_indexed | 2024-04-11T05:51:20Z |
| format | Article |
| id | doaj.art-9b5e132e83a046bf826a3f813e0568b6 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-11T05:51:20Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-9b5e132e83a046bf826a3f813e0568b62022-12-22T04:42:04ZengElsevierMaterials & Design0264-12752022-12-01224111281Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakageZhenyu Yang0Xueqiao Yu1Pengfei Wei2Yiqian Huang3Shuai Zhou4Wei Jing5Yan Zhang6Liya Sun7Guoqiang Bao8Xianli He9Bo Zhao10Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, ChinaDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, China; Foshan (Southern China) Institute for New Materials, Foshan 528220, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, ChinaBeijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, ChinaDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China; Corresponding authors.Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China; Corresponding authors.Beijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, China; Corresponding authors.Pancreatic leakage is severe and life-threatening when happening pancreatitis or conducting pancreatectomy on patients, which easily induces bleeding, infection and even death. Commercial tissue adhesives cannot meet the demands for pancreatic leakage sealing due to the weak adhesiveness, potential toxicity and inability to degrade. Few reports have been feasibly paid attention to pancreas sealants due to the complicated conditions such as enzymatic microenvironments, mechanical dynamics and pre-infections. Herein, we prepared a rapid high-adhesion, antibacterial, biodegradable and injectable bioadhesive based on the FDA-approved polyethylene glycol to seal the pancreatic leakage for clinical translations and commercial applications. The tetra-armed poly(ethylene glycol) succinimidyl glutarate (PEG-SG), tetra-armed poly(ethylene glycol) amine (PEG-NH2) and tannic acid (TA) were integrated to rapidly form the adhesive hydrogel (gelling time < 5 seconds) for convenient operations, while this bioadhesive achieved tough tissue adhesion (∼ 30 kPa), robust antibacterial activity (∼ 95% efficiency) and biocompatibility, revealing the excellent performances for pancreatic wound closure. In the established pre-clinical pancreatectomy using Bama miniature pig model, the bioadhesive presented efficient outcomes on pancreatic leakage, and this indicated the promising feasibility of the bioadhesive for clinical trials and translations.http://www.sciencedirect.com/science/article/pii/S0264127522009030Tissue adhesiveTissue sealingPEGAntibacterialPancreatic closure |
| spellingShingle | Zhenyu Yang Xueqiao Yu Pengfei Wei Yiqian Huang Shuai Zhou Wei Jing Yan Zhang Liya Sun Guoqiang Bao Xianli He Bo Zhao Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage Materials & Design Tissue adhesive Tissue sealing PEG Antibacterial Pancreatic closure |
| title | Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage |
| title_full | Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage |
| title_fullStr | Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage |
| title_full_unstemmed | Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage |
| title_short | Tetra-armed PEG-based rapid high-adhesion, antibacterial and biodegradable pre-clinical bioadhesives for preventing pancreas leakage |
| title_sort | tetra armed peg based rapid high adhesion antibacterial and biodegradable pre clinical bioadhesives for preventing pancreas leakage |
| topic | Tissue adhesive Tissue sealing PEG Antibacterial Pancreatic closure |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522009030 |
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