Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle
Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both for the physiological needs of each muscle-type...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22058-7 |
| _version_ | 1830207477744926720 |
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| author | Jerome Avellaneda Clement Rodier Fabrice Daian Nicolas Brouilly Thomas Rival Nuno Miguel Luis Frank Schnorrer |
| author_facet | Jerome Avellaneda Clement Rodier Fabrice Daian Nicolas Brouilly Thomas Rival Nuno Miguel Luis Frank Schnorrer |
| author_sort | Jerome Avellaneda |
| collection | DOAJ |
| description | Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both for the physiological needs of each muscle-type. |
| first_indexed | 2024-12-18T04:32:07Z |
| format | Article |
| id | doaj.art-9b5f30c12d544bb09b09704711b32445 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:32:07Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9b5f30c12d544bb09b09704711b324452022-12-21T21:20:57ZengNature PortfolioNature Communications2041-17232021-04-0112111810.1038/s41467-021-22058-7Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscleJerome Avellaneda0Clement Rodier1Fabrice Daian2Nicolas Brouilly3Thomas Rival4Nuno Miguel Luis5Frank Schnorrer6Aix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsAix Marseille University, CNRS, IBDM, Turing Center for Living SystemsMitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both for the physiological needs of each muscle-type.https://doi.org/10.1038/s41467-021-22058-7 |
| spellingShingle | Jerome Avellaneda Clement Rodier Fabrice Daian Nicolas Brouilly Thomas Rival Nuno Miguel Luis Frank Schnorrer Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle Nature Communications |
| title | Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| title_full | Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| title_fullStr | Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| title_full_unstemmed | Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| title_short | Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| title_sort | myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle |
| url | https://doi.org/10.1038/s41467-021-22058-7 |
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