Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies
<b>Purpose:</b> To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. <b>Data sources, selection, and extraction:</b> Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 M...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/6/2008 |
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| author | Claudia Rita Corso Natalia Mulinari Turin de Oliveira Leonardo Moura Cordeiro Karien Sauruk da Silva Suzany Hellen da Silva Soczek Virgilio Frota Rossato Elizabeth Soares Fernandes Daniele Maria-Ferreira |
| author_facet | Claudia Rita Corso Natalia Mulinari Turin de Oliveira Leonardo Moura Cordeiro Karien Sauruk da Silva Suzany Hellen da Silva Soczek Virgilio Frota Rossato Elizabeth Soares Fernandes Daniele Maria-Ferreira |
| author_sort | Claudia Rita Corso |
| collection | DOAJ |
| description | <b>Purpose:</b> To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. <b>Data sources, selection, and extraction:</b> Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. <b>Results:</b> Most of the studies explore algae polysaccharides (43.2%), followed by mushrooms (13.5%), plants (13.5%), fruits (10.8%), fungus (2.7%), bacteria, (2.7%), and sea animals (2.7%). A total of 8.1% investigated only in vitro models, 62.1% evaluated only in vivo models, and 29.7% evaluated in vitro and in vivo models. The mechanism of action involves apoptosis, inhibition of cellular proliferation, angiogenesis, and antimetastatic effects through multiple pathways. <b>Conclusions:</b> Findings included here support further investigations on the anti-tumor effect of polysaccharides. Some polysaccharides, such as fucoidan and β-glucans, deserve detailed and structured studies aiming at translational research on breast tumors, since they are already used in the clinical practice of other proposals of human health. |
| first_indexed | 2024-03-10T10:31:26Z |
| format | Article |
| id | doaj.art-9b6043fc1fcb440a900419e78e1c074f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:31:26Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9b6043fc1fcb440a900419e78e1c074f2023-11-21T23:38:42ZengMDPI AGNutrients2072-66432021-06-01136200810.3390/nu13062008Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical StudiesClaudia Rita Corso0Natalia Mulinari Turin de Oliveira1Leonardo Moura Cordeiro2Karien Sauruk da Silva3Suzany Hellen da Silva Soczek4Virgilio Frota Rossato5Elizabeth Soares Fernandes6Daniele Maria-Ferreira7Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, BrazilInstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil<b>Purpose:</b> To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. <b>Data sources, selection, and extraction:</b> Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. <b>Results:</b> Most of the studies explore algae polysaccharides (43.2%), followed by mushrooms (13.5%), plants (13.5%), fruits (10.8%), fungus (2.7%), bacteria, (2.7%), and sea animals (2.7%). A total of 8.1% investigated only in vitro models, 62.1% evaluated only in vivo models, and 29.7% evaluated in vitro and in vivo models. The mechanism of action involves apoptosis, inhibition of cellular proliferation, angiogenesis, and antimetastatic effects through multiple pathways. <b>Conclusions:</b> Findings included here support further investigations on the anti-tumor effect of polysaccharides. Some polysaccharides, such as fucoidan and β-glucans, deserve detailed and structured studies aiming at translational research on breast tumors, since they are already used in the clinical practice of other proposals of human health.https://www.mdpi.com/2072-6643/13/6/2008polysaccharidesbreast cancercancer treatmentnonclinical studiesnatural source |
| spellingShingle | Claudia Rita Corso Natalia Mulinari Turin de Oliveira Leonardo Moura Cordeiro Karien Sauruk da Silva Suzany Hellen da Silva Soczek Virgilio Frota Rossato Elizabeth Soares Fernandes Daniele Maria-Ferreira Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies Nutrients polysaccharides breast cancer cancer treatment nonclinical studies natural source |
| title | Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies |
| title_full | Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies |
| title_fullStr | Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies |
| title_full_unstemmed | Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies |
| title_short | Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies |
| title_sort | polysaccharides with antitumor effect in breast cancer a systematic review of non clinical studies |
| topic | polysaccharides breast cancer cancer treatment nonclinical studies natural source |
| url | https://www.mdpi.com/2072-6643/13/6/2008 |
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