CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease

CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease

The study aimed to compare composition of peripheral blood T-cell subsets and assess their surface expression of CD39 and CD73 ectonucleotidases in patients with severe and moderate aortic stenosis (AS) as well as to evaluate involvement of T-cell-mediated immune processes in valve calcification. Th...

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Bibliographic Details
Main Authors: Igor Kudryavtsev, Maria Serebriakova, Ekaterina Zhiduleva, Patimat Murtazalieva, Vladislav Titov, Anna Malashicheva, Anastasya Shishkova, Daria Semenova, Olga Irtyuga, Dmitry Isakov, Lubov Mitrofanova, Olga Moiseeva, Alexey Golovkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
calcified aortic stenosis
T-cells (or lymphocytes)
purinergic signaling
calcification
CD39 and CD73 expression
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00604/full

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