The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol
Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol an...
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MDPI AG
2016-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/1/127 |
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| author | Peter Kotora František Šeršeň Juraj Filo Dušan Loos Juraj Gregáň Fridrich Gregáň |
| author_facet | Peter Kotora František Šeršeň Juraj Filo Dušan Loos Juraj Gregáň Fridrich Gregáň |
| author_sort | Peter Kotora |
| collection | DOAJ |
| description | Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs. |
| first_indexed | 2024-12-11T19:49:36Z |
| format | Article |
| id | doaj.art-9b63a3eab065428bbbecb961f11fac6c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T19:49:36Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9b63a3eab065428bbbecb961f11fac6c2022-12-22T00:52:49ZengMDPI AGMolecules1420-30492016-01-0121112710.3390/molecules21010127molecules21010127The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of ResveratrolPeter Kotora0František Šeršeň1Juraj Filo2Dušan Loos3Juraj Gregáň4Fridrich Gregáň5Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, SlovakiaInstitute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, SlovakiaInstitute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, SlovakiaInstitute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, SlovakiaDepartment of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, SlovakiaDepartment of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, 974 01 Banská Bystrica, SlovakiaResveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.http://www.mdpi.com/1420-3049/21/1/127resveratrol analogsiminophenolsantioxidant activity |
| spellingShingle | Peter Kotora František Šeršeň Juraj Filo Dušan Loos Juraj Gregáň Fridrich Gregáň The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol Molecules resveratrol analogs iminophenols antioxidant activity |
| title | The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol |
| title_full | The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol |
| title_fullStr | The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol |
| title_full_unstemmed | The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol |
| title_short | The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol |
| title_sort | scavenging of dpph galvinoxyl and abts radicals by imine analogs of resveratrol |
| topic | resveratrol analogs iminophenols antioxidant activity |
| url | http://www.mdpi.com/1420-3049/21/1/127 |
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