Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues
Osteoarthritis (OA) is the most common joint disease, and good therapeutic results are often difficult to obtain due to its complex pathogenesis and diverse causative factors. After decades of research and exploration of OA, it has been progressively found that subchondral bone is essential for its...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-03-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024017 |
| _version_ | 1797208518212714496 |
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| author | Chen Wenlong Wang Qiufei Tao Huaqiang Lu Lingfeng Zhou Jing Wang Qiang Huang Wei Yang Xing |
| author_facet | Chen Wenlong Wang Qiufei Tao Huaqiang Lu Lingfeng Zhou Jing Wang Qiang Huang Wei Yang Xing |
| author_sort | Chen Wenlong |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common joint disease, and good therapeutic results are often difficult to obtain due to its complex pathogenesis and diverse causative factors. After decades of research and exploration of OA, it has been progressively found that subchondral bone is essential for its pathogenesis, and pathological changes in subchondral bone can be observed even before cartilage lesions develop. Osteoclasts, the main cells regulating bone resorption, play a crucial role in the pathogenesis of subchondral bone. Subchondral osteoclasts regulate the homeostasis of subchondral bone through the secretion of degradative enzymes, immunomodulation, and cell signaling pathways. In OA, osteoclasts are overactivated by autophagy, ncRNAs, and Rankl/Rank/OPG signaling pathways. Excessive bone resorption disrupts the balance of bone remodeling, leading to increased subchondral bone loss, decreased bone mineral density and consequent structural damage to articular cartilage and joint pain. With increased understanding of bone biology and targeted therapies, researchers have found that the activity and function of subchondral osteoclasts are affected by multiple pathways. In this review, we summarize the roles and mechanisms of subchondral osteoclasts in OA, enumerate the latest advances in subchondral osteoclast-targeted therapy for OA, and look forward to the future trends of subchondral osteoclast-targeted therapies in clinical applications to fill the gaps in the current knowledge of OA treatment and to develop new therapeutic strategies. |
| first_indexed | 2024-04-24T09:40:05Z |
| format | Article |
| id | doaj.art-9b67050540414001a51b888c4bdd4af5 |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-04-24T09:40:05Z |
| publishDate | 2024-03-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-9b67050540414001a51b888c4bdd4af52024-04-15T07:14:57ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-03-015649951210.3724/abbs.202401720d259ccSubchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenuesChen Wenlong0Wang Qiufei1Tao Huaqiang2Lu Lingfeng3Zhou Jing4Wang Qiang5Huang Wei6Yang Xing7["Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215000, China","Gusu School, Nanjing Medical University, Suzhou 215000, China"]["Department of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou 215000, China"]["Department of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou 215000, China"]["Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215000, China","Gusu School, Nanjing Medical University, Suzhou 215000, China"]["Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215000, China","Gusu School, Nanjing Medical University, Suzhou 215000, China"]["Department of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou 215000, China"]["Department of Orthopaedics, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"]["Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215000, China","Gusu School, Nanjing Medical University, Suzhou 215000, China"]Osteoarthritis (OA) is the most common joint disease, and good therapeutic results are often difficult to obtain due to its complex pathogenesis and diverse causative factors. After decades of research and exploration of OA, it has been progressively found that subchondral bone is essential for its pathogenesis, and pathological changes in subchondral bone can be observed even before cartilage lesions develop. Osteoclasts, the main cells regulating bone resorption, play a crucial role in the pathogenesis of subchondral bone. Subchondral osteoclasts regulate the homeostasis of subchondral bone through the secretion of degradative enzymes, immunomodulation, and cell signaling pathways. In OA, osteoclasts are overactivated by autophagy, ncRNAs, and Rankl/Rank/OPG signaling pathways. Excessive bone resorption disrupts the balance of bone remodeling, leading to increased subchondral bone loss, decreased bone mineral density and consequent structural damage to articular cartilage and joint pain. With increased understanding of bone biology and targeted therapies, researchers have found that the activity and function of subchondral osteoclasts are affected by multiple pathways. In this review, we summarize the roles and mechanisms of subchondral osteoclasts in OA, enumerate the latest advances in subchondral osteoclast-targeted therapy for OA, and look forward to the future trends of subchondral osteoclast-targeted therapies in clinical applications to fill the gaps in the current knowledge of OA treatment and to develop new therapeutic strategies.https://www.sciengine.com/doi/10.3724/abbs.2024017osteoarthritisosteoclastsubchondral bone |
| spellingShingle | Chen Wenlong Wang Qiufei Tao Huaqiang Lu Lingfeng Zhou Jing Wang Qiang Huang Wei Yang Xing Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues Acta Biochimica et Biophysica Sinica osteoarthritis osteoclast subchondral bone |
| title | Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues |
| title_full | Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues |
| title_fullStr | Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues |
| title_full_unstemmed | Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues |
| title_short | Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues |
| title_sort | subchondral osteoclasts and osteoarthritis new insights and potential therapeutic avenues |
| topic | osteoarthritis osteoclast subchondral bone |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024017 |
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