Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13
Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for thrombosis and inflammation. During these processes, a complex series of events, including endothelial activation, NET formation, VWF secretion, and blood cell adhesion, aggregation and activation, occurs in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.610696/full |
| _version_ | 1819171585981939712 |
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| author | Junxian Yang Junxian Yang Zhiwei Wu Zhiwei Wu Quan Long Jiaqi Huang Tiantian Hong Tiantian Hong Wang Liu Jiangguo Lin Jiangguo Lin |
| author_facet | Junxian Yang Junxian Yang Zhiwei Wu Zhiwei Wu Quan Long Jiaqi Huang Tiantian Hong Tiantian Hong Wang Liu Jiangguo Lin Jiangguo Lin |
| author_sort | Junxian Yang |
| collection | DOAJ |
| description | Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for thrombosis and inflammation. During these processes, a complex series of events, including endothelial activation, NET formation, VWF secretion, and blood cell adhesion, aggregation and activation, occurs in an ordered manner in the vasculature. The adhesive activity of VWF multimers is regulated by a specific metalloprotease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13). Increasing evidence indicates that the interaction between NETs and VWF contributes to arterial and venous thrombosis as well as inflammation. Furthermore, contents released from activated neutrophils or NETs induce the reduction of ADAMTS13 activity, which may occur in both thrombotic microangiopathies (TMAs) and acute ischemic stroke (AIS). Recently, NET is considered as a driver of endothelial damage and immunothrombosis in COVID-19. In addition, the levels of VWF and ADAMTS13 can predict the mortality of COVID-19. In this review, we summarize the biological characteristics and interactions of NETs, VWF, and ADAMTS13, and discuss their roles in TMAs, AIS, and COVID-19. Targeting the NET-VWF axis may be a novel therapeutic strategy for inflammation-associated TMAs, AIS, and COVID-19. |
| first_indexed | 2024-12-22T19:53:38Z |
| format | Article |
| id | doaj.art-9b67522bb9934706b685b2e0200d98dd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T19:53:38Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9b67522bb9934706b685b2e0200d98dd2022-12-21T18:14:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-12-011110.3389/fimmu.2020.610696610696Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13Junxian Yang0Junxian Yang1Zhiwei Wu2Zhiwei Wu3Quan Long4Jiaqi Huang5Tiantian Hong6Tiantian Hong7Wang Liu8Jiangguo Lin9Jiangguo Lin10Research Department of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaResearch Department of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaResearch Department of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaResearch Department of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaInstitute of Biomechanics/School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, ChinaBoth neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for thrombosis and inflammation. During these processes, a complex series of events, including endothelial activation, NET formation, VWF secretion, and blood cell adhesion, aggregation and activation, occurs in an ordered manner in the vasculature. The adhesive activity of VWF multimers is regulated by a specific metalloprotease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13). Increasing evidence indicates that the interaction between NETs and VWF contributes to arterial and venous thrombosis as well as inflammation. Furthermore, contents released from activated neutrophils or NETs induce the reduction of ADAMTS13 activity, which may occur in both thrombotic microangiopathies (TMAs) and acute ischemic stroke (AIS). Recently, NET is considered as a driver of endothelial damage and immunothrombosis in COVID-19. In addition, the levels of VWF and ADAMTS13 can predict the mortality of COVID-19. In this review, we summarize the biological characteristics and interactions of NETs, VWF, and ADAMTS13, and discuss their roles in TMAs, AIS, and COVID-19. Targeting the NET-VWF axis may be a novel therapeutic strategy for inflammation-associated TMAs, AIS, and COVID-19.https://www.frontiersin.org/articles/10.3389/fimmu.2020.610696/fullneutrophil extracellular trapsvon Willebrand factorADAMTS13thrombotic microangiopathyacute ischemic strokeCOVID-19 |
| spellingShingle | Junxian Yang Junxian Yang Zhiwei Wu Zhiwei Wu Quan Long Jiaqi Huang Tiantian Hong Tiantian Hong Wang Liu Jiangguo Lin Jiangguo Lin Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 Frontiers in Immunology neutrophil extracellular traps von Willebrand factor ADAMTS13 thrombotic microangiopathy acute ischemic stroke COVID-19 |
| title | Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 |
| title_full | Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 |
| title_fullStr | Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 |
| title_full_unstemmed | Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 |
| title_short | Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13 |
| title_sort | insights into immunothrombosis the interplay among neutrophil extracellular trap von willebrand factor and adamts13 |
| topic | neutrophil extracellular traps von Willebrand factor ADAMTS13 thrombotic microangiopathy acute ischemic stroke COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.610696/full |
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