COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS
Modern options of uterine fibroids pharmacotherapy allow for individual selection of therapy. Aim. To compare the effectiveness of uterine fibroids treatment with administration of mifepristone (Gynestril) on the basis of a differentiated approach to the assignment of two treatment schedules in vari...
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2017-10-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/833 |
| _version_ | 1797295488747175936 |
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| author | V. E. Radzinsky I. M. Ordiyants V. A. Khorolsky |
| author_facet | V. E. Radzinsky I. M. Ordiyants V. A. Khorolsky |
| author_sort | V. E. Radzinsky |
| collection | DOAJ |
| description | Modern options of uterine fibroids pharmacotherapy allow for individual selection of therapy. Aim. To compare the effectiveness of uterine fibroids treatment with administration of mifepristone (Gynestril) on the basis of a differentiated approach to the assignment of two treatment schedules in various dosages: 25 mg or 50 mg per day for three months.Materials and methods. A prospective comparative study was conducted at the clinical bases of Department of Obstetrics and Gynecology with the Course of Perinatology of the Peoples’ Friendship University of Russia (Moscow) and the Department of Obstetrics, Gynecology and Perinatology of the Kuban State Medical University (Krasnodar). 160 women with uterine myoma were enrolled in the clinical groups. Randomization was carried out by a double-blind method using envelopes.Results. Administration of mifepristone (Gynestril) at a dosage of 50 mg per day for 12 weeks and 25 mg per day for 24 weeks has comparable efficacy.Conclusion. Due to the assessment of subjective and objective criteria of drug tolerance, an individual dose selection of mifepristone is possible without compromising the achievement of the therapeutic effect. |
| first_indexed | 2024-03-07T21:48:43Z |
| format | Article |
| id | doaj.art-9b684c6e5543476fb42818d4e8d60357 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:48:43Z |
| publishDate | 2017-10-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-9b684c6e5543476fb42818d4e8d603572024-02-25T10:57:21ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442017-10-010411512110.25207/1608-6228-2017-24-4-115-121795COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDSV. E. Radzinsky0I. M. Ordiyants1V. A. Khorolsky2Peoples’ Friendship University of RussiaPeoples’ Friendship University of RussiaKuban State Medical UniversityModern options of uterine fibroids pharmacotherapy allow for individual selection of therapy. Aim. To compare the effectiveness of uterine fibroids treatment with administration of mifepristone (Gynestril) on the basis of a differentiated approach to the assignment of two treatment schedules in various dosages: 25 mg or 50 mg per day for three months.Materials and methods. A prospective comparative study was conducted at the clinical bases of Department of Obstetrics and Gynecology with the Course of Perinatology of the Peoples’ Friendship University of Russia (Moscow) and the Department of Obstetrics, Gynecology and Perinatology of the Kuban State Medical University (Krasnodar). 160 women with uterine myoma were enrolled in the clinical groups. Randomization was carried out by a double-blind method using envelopes.Results. Administration of mifepristone (Gynestril) at a dosage of 50 mg per day for 12 weeks and 25 mg per day for 24 weeks has comparable efficacy.Conclusion. Due to the assessment of subjective and objective criteria of drug tolerance, an individual dose selection of mifepristone is possible without compromising the achievement of the therapeutic effect.https://ksma.elpub.ru/jour/article/view/833uterine fibroidspharmacotherapyantigestagenmifepristonegynestril |
| spellingShingle | V. E. Radzinsky I. M. Ordiyants V. A. Khorolsky COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS Кубанский научный медицинский вестник uterine fibroids pharmacotherapy antigestagen mifepristone gynestril |
| title | COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS |
| title_full | COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS |
| title_fullStr | COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS |
| title_full_unstemmed | COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS |
| title_short | COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS |
| title_sort | comparative effectiveness of two schedules of gynestril administration in treatment of uterine fibroids |
| topic | uterine fibroids pharmacotherapy antigestagen mifepristone gynestril |
| url | https://ksma.elpub.ru/jour/article/view/833 |
| work_keys_str_mv | AT veradzinsky comparativeeffectivenessoftwoschedulesofgynestriladministrationintreatmentofuterinefibroids AT imordiyants comparativeeffectivenessoftwoschedulesofgynestriladministrationintreatmentofuterinefibroids AT vakhorolsky comparativeeffectivenessoftwoschedulesofgynestriladministrationintreatmentofuterinefibroids |