CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2015-04-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/837 |
| _version_ | 1797197964207194112 |
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| author | I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache |
| author_facet | I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache |
| author_sort | I. G. Kulikova |
| collection | DOAJ |
| description | The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The immune assays were conducted in parallel, using multiplex cytokine analysis (flow cytometry technique), and leukocyte inhibition migration reaction. Twenty-six patients with different forms of ophthalmic pathology were examined, including cases of uveitis (18), keratouveitis (3), glaucoma (5). It is shown that the reduced TGF-β1 levels and increased concentrations of proinflammatory, chemotactic cytokines in AEC liquid are associated with development of organ-specific immune sensitization. |
| first_indexed | 2024-03-08T05:49:56Z |
| format | Article |
| id | doaj.art-9b6990712bd64dd09f3e406c0e116849 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:19Z |
| publishDate | 2015-04-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-9b6990712bd64dd09f3e406c0e1168492024-04-22T13:07:40ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2015-04-0117217918210.15789/1563-0625-2015-2-179-182750CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENSI. G. Kulikova0O. S. Slepova1E. V. Denisova2L. A. Kovaleva3P. V. Makarov4D. N. Lovpache5The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The immune assays were conducted in parallel, using multiplex cytokine analysis (flow cytometry technique), and leukocyte inhibition migration reaction. Twenty-six patients with different forms of ophthalmic pathology were examined, including cases of uveitis (18), keratouveitis (3), glaucoma (5). It is shown that the reduced TGF-β1 levels and increased concentrations of proinflammatory, chemotactic cytokines in AEC liquid are associated with development of organ-specific immune sensitization.https://www.mimmun.ru/mimmun/article/view/837cytokinesanterior eye chamberorgan-specific autoimmunitymultiplex analysismigration inhibition testleukocytesophthalmopathology |
| spellingShingle | I. G. Kulikova O. S. Slepova E. V. Denisova L. A. Kovaleva P. V. Makarov D. N. Lovpache CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS Медицинская иммунология cytokines anterior eye chamber organ-specific autoimmunity multiplex analysis migration inhibition test leukocytes ophthalmopathology |
| title | CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS |
| title_full | CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS |
| title_fullStr | CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS |
| title_full_unstemmed | CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS |
| title_short | CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS |
| title_sort | cytokines in anterior eye chamber liquid their role in development of systemic immune response to ocular tissue antigens |
| topic | cytokines anterior eye chamber organ-specific autoimmunity multiplex analysis migration inhibition test leukocytes ophthalmopathology |
| url | https://www.mimmun.ru/mimmun/article/view/837 |
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