Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study
Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who un...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Sports and Active Living |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fspor.2023.1092050/full |
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| author | Carolina F. Nicoletti Carolina F. Nicoletti Hamilton Roschel Carlos Merege-Filho Alisson P. Lima Saulo Gil Marcela A. S. Pinhel Marcela A. S. Pinhel Natalia Y. Noronha Marco A. Santo Amalia Jacome Ana B. Crujeiras Bruno Gualano Carla B. Nonino |
| author_facet | Carolina F. Nicoletti Carolina F. Nicoletti Hamilton Roschel Carlos Merege-Filho Alisson P. Lima Saulo Gil Marcela A. S. Pinhel Marcela A. S. Pinhel Natalia Y. Noronha Marco A. Santo Amalia Jacome Ana B. Crujeiras Bruno Gualano Carla B. Nonino |
| author_sort | Carolina F. Nicoletti |
| collection | DOAJ |
| description | Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. In this exploratory, quasi-experimental study, we analyzed DNA methylation levels by array technology in eleven women who underwent Roux-en-Y Gastric Bypass and a 6-month, three-times-a-week, supervised exercise training program. Epigenome Wide Association Analysis showed 722 CpG sites with different methylation level equal to or greater than 5% (P < 0.01) after exercise training. Some of these CpGs sites were related to pathophysiological mechanisms of inflammation, specially Th17 cell differentiation (FDR value < 0.05 and P < 0.001). Our data showed epigenetic modification in specific CpG sites related to Th17 cell differentiation pathway in post-bariatric women following a 6-months exercise training program. |
| first_indexed | 2024-04-10T16:42:21Z |
| format | Article |
| id | doaj.art-9b6b5b4e5cbe4298a677bc1c9fe4c4c2 |
| institution | Directory Open Access Journal |
| issn | 2624-9367 |
| language | English |
| last_indexed | 2024-04-10T16:42:21Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sports and Active Living |
| spelling | doaj.art-9b6b5b4e5cbe4298a677bc1c9fe4c4c22023-02-08T06:38:45ZengFrontiers Media S.A.Frontiers in Sports and Active Living2624-93672023-02-01510.3389/fspor.2023.10920501092050Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory studyCarolina F. Nicoletti0Carolina F. Nicoletti1Hamilton Roschel2Carlos Merege-Filho3Alisson P. Lima4Saulo Gil5Marcela A. S. Pinhel6Marcela A. S. Pinhel7Natalia Y. Noronha8Marco A. Santo9Amalia Jacome10Ana B. Crujeiras11Bruno Gualano12Carla B. Nonino13Department of Internal Medicine, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão preto, BrazilApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilDepartment of Internal Medicine, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão preto, BrazilLaboratory of Studies in Biochemistry and Molecular Biology, Department of Molecular Biology, São José do Rio Preto Medical School, Sao Jose do Rio Preto, BrazilDepartment of Internal Medicine, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão preto, BrazilDepartment of Digestive Surgery, School of Medicine, University of Paulo, Sao Paulo, BrazilDepartment of Mathematics, MODES Group, CITIC, Universidade da Coruña, Faculty of Science, A coruña, SpainEpigenomics in Endocrinology and Nutrition, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Madrid, SpainApplied Physiology & Nutrition Research Group, School of Physical Educaton and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao paulo, BrazilDepartment of Health Science, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão preto, BrazilExercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. In this exploratory, quasi-experimental study, we analyzed DNA methylation levels by array technology in eleven women who underwent Roux-en-Y Gastric Bypass and a 6-month, three-times-a-week, supervised exercise training program. Epigenome Wide Association Analysis showed 722 CpG sites with different methylation level equal to or greater than 5% (P < 0.01) after exercise training. Some of these CpGs sites were related to pathophysiological mechanisms of inflammation, specially Th17 cell differentiation (FDR value < 0.05 and P < 0.001). Our data showed epigenetic modification in specific CpG sites related to Th17 cell differentiation pathway in post-bariatric women following a 6-months exercise training program.https://www.frontiersin.org/articles/10.3389/fspor.2023.1092050/fullobesityDNA methylationepigeneticexercise programth7 cell differentiation |
| spellingShingle | Carolina F. Nicoletti Carolina F. Nicoletti Hamilton Roschel Carlos Merege-Filho Alisson P. Lima Saulo Gil Marcela A. S. Pinhel Marcela A. S. Pinhel Natalia Y. Noronha Marco A. Santo Amalia Jacome Ana B. Crujeiras Bruno Gualano Carla B. Nonino Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study Frontiers in Sports and Active Living obesity DNA methylation epigenetic exercise program th7 cell differentiation |
| title | Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study |
| title_full | Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study |
| title_fullStr | Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study |
| title_full_unstemmed | Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study |
| title_short | Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study |
| title_sort | exercise training and dna methylation profile in post bariatric women results from an exploratory study |
| topic | obesity DNA methylation epigenetic exercise program th7 cell differentiation |
| url | https://www.frontiersin.org/articles/10.3389/fspor.2023.1092050/full |
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