Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects
Computerized texture analysis uses higher-order mathematics to identify patterns beyond what the naked eye can recognize. We tested its feasibility in optical coherence tomography angiography imaging of choriocapillaris. Our objective was to determine sets of parameters that provide coherent and con...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/12/1934 |
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| author | Asadolah Movahedan Phillip Vargas John Moir Gabriel Kaufmann Lindsay Chun Claire Smith Nathalie Massamba Patrick La Riviere Dimitra Skondra |
| author_facet | Asadolah Movahedan Phillip Vargas John Moir Gabriel Kaufmann Lindsay Chun Claire Smith Nathalie Massamba Patrick La Riviere Dimitra Skondra |
| author_sort | Asadolah Movahedan |
| collection | DOAJ |
| description | Computerized texture analysis uses higher-order mathematics to identify patterns beyond what the naked eye can recognize. We tested its feasibility in optical coherence tomography angiography imaging of choriocapillaris. Our objective was to determine sets of parameters that provide coherent and consistent output when applied to a homogeneous, healthy group of patients. This observational cross-sectional study involved 19 eyes of 10 young and healthy Caucasian subjects. En-face macular optical coherence tomography angiography of superficial choriocapillaris was obtained by the RTVue-XR Avanti system. Various algorithms were used to extract texture features. The mean and standard deviation were used to assess the distribution and dispersion of data points in each metric among eyes, which included: average gray level, gray level yielding 70% threshold and 30% threshold, balance, skewness, energy, entropy, contrast, edge mean gradient, root-mean-square variation, and first moment of power spectrum, which was compared between images, showing a highly concordant homology between all eyes of participants. We conclude that computerized texture analysis for en-face optical coherence tomography angiography images of choriocapillaris is feasible and provides values that are coherent and tightly distributed around the mean in a homogenous, healthy group of patients. Homology of blob size among subjects may represent a “repeat pattern” in signal density and thus a perfusion in the superficial choriocapillaris of healthy young individuals of the same ethnic background. |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:17Z |
| publishDate | 2022-06-01 |
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| series | Cells |
| spelling | doaj.art-9b703f55b3384d30a3f5a20e24cc4c762023-11-23T16:01:46ZengMDPI AGCells2073-44092022-06-011112193410.3390/cells11121934Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy SubjectsAsadolah Movahedan0Phillip Vargas1John Moir2Gabriel Kaufmann3Lindsay Chun4Claire Smith5Nathalie Massamba6Patrick La Riviere7Dimitra Skondra8J. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USADepartment of Radiology, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USADepartment of Radiology, The University of Chicago, Chicago, IL 60637, USAJ. Terry Ernest Ocular Imaging Center, Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USAComputerized texture analysis uses higher-order mathematics to identify patterns beyond what the naked eye can recognize. We tested its feasibility in optical coherence tomography angiography imaging of choriocapillaris. Our objective was to determine sets of parameters that provide coherent and consistent output when applied to a homogeneous, healthy group of patients. This observational cross-sectional study involved 19 eyes of 10 young and healthy Caucasian subjects. En-face macular optical coherence tomography angiography of superficial choriocapillaris was obtained by the RTVue-XR Avanti system. Various algorithms were used to extract texture features. The mean and standard deviation were used to assess the distribution and dispersion of data points in each metric among eyes, which included: average gray level, gray level yielding 70% threshold and 30% threshold, balance, skewness, energy, entropy, contrast, edge mean gradient, root-mean-square variation, and first moment of power spectrum, which was compared between images, showing a highly concordant homology between all eyes of participants. We conclude that computerized texture analysis for en-face optical coherence tomography angiography images of choriocapillaris is feasible and provides values that are coherent and tightly distributed around the mean in a homogenous, healthy group of patients. Homology of blob size among subjects may represent a “repeat pattern” in signal density and thus a perfusion in the superficial choriocapillaris of healthy young individuals of the same ethnic background.https://www.mdpi.com/2073-4409/11/12/1934computerized texture analysisoptical coherence tomography angiographychoriocapillaris |
| spellingShingle | Asadolah Movahedan Phillip Vargas John Moir Gabriel Kaufmann Lindsay Chun Claire Smith Nathalie Massamba Patrick La Riviere Dimitra Skondra Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects Cells computerized texture analysis optical coherence tomography angiography choriocapillaris |
| title | Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects |
| title_full | Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects |
| title_fullStr | Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects |
| title_full_unstemmed | Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects |
| title_short | Computerized Texture Analysis of Optical Coherence Tomography Angiography of Choriocapillaris in Normal Eyes of Young and Healthy Subjects |
| title_sort | computerized texture analysis of optical coherence tomography angiography of choriocapillaris in normal eyes of young and healthy subjects |
| topic | computerized texture analysis optical coherence tomography angiography choriocapillaris |
| url | https://www.mdpi.com/2073-4409/11/12/1934 |
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