Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge
Abstract Background: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal seg...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
2018-12-01
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005020106&lng=en&tlng=en |
| _version_ | 1811216176860102656 |
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| author | Asim Enhos Kahraman Cosansu Mustafa Ahmet Huyut Fahrettin Turna Erdem Karacop Nijad Bakshaliyev Aydin Nadir Ramazan Ozdemir Mahmut Uluganyan |
| author_facet | Asim Enhos Kahraman Cosansu Mustafa Ahmet Huyut Fahrettin Turna Erdem Karacop Nijad Bakshaliyev Aydin Nadir Ramazan Ozdemir Mahmut Uluganyan |
| author_sort | Asim Enhos |
| collection | DOAJ |
| description | Abstract Background: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. Results: MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. Conclusion: The present study revealed a significant correlation between MHR and MB. |
| first_indexed | 2024-04-12T06:34:48Z |
| format | Article |
| id | doaj.art-9b74ab5b474d425fa5635e68737381ad |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-04-12T06:34:48Z |
| publishDate | 2018-12-01 |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-9b74ab5b474d425fa5635e68737381ad2022-12-22T03:43:55ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41702018-12-01010.5935/abc.20180253S0066-782X2018005020106Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial BridgeAsim EnhosKahraman CosansuMustafa Ahmet HuyutFahrettin TurnaErdem KaracopNijad BakshaliyevAydin NadirRamazan OzdemirMahmut UluganyanAbstract Background: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. Results: MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. Conclusion: The present study revealed a significant correlation between MHR and MB.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005020106&lng=en&tlng=enBiomarkers/bloodCholesterol, HDL/bloodMonocytes/citologyMyocardial BridgingAtherosclerosisInflammation |
| spellingShingle | Asim Enhos Kahraman Cosansu Mustafa Ahmet Huyut Fahrettin Turna Erdem Karacop Nijad Bakshaliyev Aydin Nadir Ramazan Ozdemir Mahmut Uluganyan Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge Arquivos Brasileiros de Cardiologia Biomarkers/blood Cholesterol, HDL/blood Monocytes/citology Myocardial Bridging Atherosclerosis Inflammation |
| title | Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge |
| title_full | Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge |
| title_fullStr | Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge |
| title_full_unstemmed | Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge |
| title_short | Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge |
| title_sort | assessment of the relationship between monocyte to high density lipoprotein ratio and myocardial bridge |
| topic | Biomarkers/blood Cholesterol, HDL/blood Monocytes/citology Myocardial Bridging Atherosclerosis Inflammation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005020106&lng=en&tlng=en |
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