The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy
Abstract Background To evaluate myocardial work using speckle tracking echocardiography in patients with non-obstructive hypertrophic cardiomyopathy (HCM). Methods Fifty patients with HCM and 50 normal controls were included. Left ventricular ejection fraction (LVEF) was quantified using the bi-plan...
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BMC
2022-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02740-4 |
| _version_ | 1818518336079659008 |
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| author | Chenguang Yang Ying Guo Xiang Wang Ruisheng Zhang Fang Wang Huolan Zhu |
| author_facet | Chenguang Yang Ying Guo Xiang Wang Ruisheng Zhang Fang Wang Huolan Zhu |
| author_sort | Chenguang Yang |
| collection | DOAJ |
| description | Abstract Background To evaluate myocardial work using speckle tracking echocardiography in patients with non-obstructive hypertrophic cardiomyopathy (HCM). Methods Fifty patients with HCM and 50 normal controls were included. Left ventricular ejection fraction (LVEF) was quantified using the bi-plane Simpson’s method. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE), were derived from the 2D strain-pressure loop. Results The patient group was older (49.19 ± 14.69 vs. 37.16 ± 7.49 years old) and had a higher body mass index (24.93 ± 3.67 vs. 23.26 ± 3.32 kg/m2) and systolic blood pressure (121.81 ± 16.50 vs. 115.30 ± 11.01 mmHg) (P < 0.05). The mean LVEF in patients was 51%, with 54% of patients had LVEF ≤ 50%. Compared to controls, GWI (946.42 ± 360.64 vs. 1639.72 ± 204.56 mmHg%), GCW (1176.94 ± 373.23 vs. 1960.16 ± 255.72 mmHg%), and GWE (83.96 ± 7.68 vs. 95.26 ± 1.98%) were significantly decreased, while GWW (158.17 ± 82.47 vs. 79.12 ± 40.26 mmHg%) was significantly increased (P < 0.05) in the patient group. In patients, GWE showed a trend of positive correlation with LVEF (r = 0.276, P = 0.06), while GWW had a trend of negative correlation with LVEF (r = − 0.241, P = 0.09). No correlation between myocardial work and LV diastolic function or QRS duration was observed. Maximal wall thickness significantly correlated with all the myocardial work parameters. Conclusions Assessing myocardial work adds useful information of LV function in patients with non-obstructive HCM. |
| first_indexed | 2024-12-11T01:08:55Z |
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| id | doaj.art-9b79ae02ceb240afafee5b075873c207 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-11T01:08:55Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-9b79ae02ceb240afafee5b075873c2072022-12-22T01:26:06ZengBMCBMC Cardiovascular Disorders1471-22612022-07-012211810.1186/s12872-022-02740-4The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathyChenguang Yang0Ying Guo1Xiang Wang2Ruisheng Zhang3Fang Wang4Huolan Zhu5Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Gerontology, Shaanxi Provincial People’s Hospital, Shaanxi Provincial Clinical Research Center for Geriatric MedicineAbstract Background To evaluate myocardial work using speckle tracking echocardiography in patients with non-obstructive hypertrophic cardiomyopathy (HCM). Methods Fifty patients with HCM and 50 normal controls were included. Left ventricular ejection fraction (LVEF) was quantified using the bi-plane Simpson’s method. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE), were derived from the 2D strain-pressure loop. Results The patient group was older (49.19 ± 14.69 vs. 37.16 ± 7.49 years old) and had a higher body mass index (24.93 ± 3.67 vs. 23.26 ± 3.32 kg/m2) and systolic blood pressure (121.81 ± 16.50 vs. 115.30 ± 11.01 mmHg) (P < 0.05). The mean LVEF in patients was 51%, with 54% of patients had LVEF ≤ 50%. Compared to controls, GWI (946.42 ± 360.64 vs. 1639.72 ± 204.56 mmHg%), GCW (1176.94 ± 373.23 vs. 1960.16 ± 255.72 mmHg%), and GWE (83.96 ± 7.68 vs. 95.26 ± 1.98%) were significantly decreased, while GWW (158.17 ± 82.47 vs. 79.12 ± 40.26 mmHg%) was significantly increased (P < 0.05) in the patient group. In patients, GWE showed a trend of positive correlation with LVEF (r = 0.276, P = 0.06), while GWW had a trend of negative correlation with LVEF (r = − 0.241, P = 0.09). No correlation between myocardial work and LV diastolic function or QRS duration was observed. Maximal wall thickness significantly correlated with all the myocardial work parameters. Conclusions Assessing myocardial work adds useful information of LV function in patients with non-obstructive HCM.https://doi.org/10.1186/s12872-022-02740-4EchocardiographyHypertrophic cardiomyopathyMyocardial workSpeckle tracking |
| spellingShingle | Chenguang Yang Ying Guo Xiang Wang Ruisheng Zhang Fang Wang Huolan Zhu The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy BMC Cardiovascular Disorders Echocardiography Hypertrophic cardiomyopathy Myocardial work Speckle tracking |
| title | The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy |
| title_full | The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy |
| title_fullStr | The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy |
| title_full_unstemmed | The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy |
| title_short | The value of myocardial work in assessment of ventricular function in patients with non-obstructive hypertrophic cardiomyopathy |
| title_sort | value of myocardial work in assessment of ventricular function in patients with non obstructive hypertrophic cardiomyopathy |
| topic | Echocardiography Hypertrophic cardiomyopathy Myocardial work Speckle tracking |
| url | https://doi.org/10.1186/s12872-022-02740-4 |
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