Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds
Abstract Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals – the most successful orthopedic material – have yet to...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202302702 |
| _version_ | 1827817661384359936 |
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| author | Juncen Zhou Elias Georgas Yingchao Su Jiayi Zhou Nadja Kröger Felix Benn Alexander Kopp Yi‐Xian Qin Donghui Zhu |
| author_facet | Juncen Zhou Elias Georgas Yingchao Su Jiayi Zhou Nadja Kröger Felix Benn Alexander Kopp Yi‐Xian Qin Donghui Zhu |
| author_sort | Juncen Zhou |
| collection | DOAJ |
| description | Abstract Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals – the most successful orthopedic material – have yet to yield satisfactory results. Conventional bio‐inert metals, such as titanium (Ti) and its alloys, are widely used for fixation devices and reconstructive implants, but their non‐bioresorbable nature and the mechanical property mismatch with human bones limit their application as porous scaffolds for bone regeneration. Advancements in additive manufacturing have facilitated the use of bioresorbable metals, including magnesium (Mg), zinc (Zn), and their alloys, as porous scaffolds via Laser Powder Bed Fusion (L‐PBF) technology. This in vivo study presents a comprehensive, side‐by‐side comparative analysis of the interactions between bone regeneration and additively manufactured bio‐inert/bioresorbable metal scaffolds, as well as their therapeutic outcomes. The research offers an in‐depth understanding of the metal scaffold‐assisted bone healing process, illustrating that Mg and Zn scaffolds contribute to the bone healing process in distinct ways, but ultimately deliver superior therapeutic outcomes compared to Ti scaffolds. These findings suggest that bioresorbable metal scaffolds hold considerable promise for the clinical treatment of bone defects in the near future. |
| first_indexed | 2024-03-12T00:37:20Z |
| format | Article |
| id | doaj.art-9b7bd7a63c294e9f9871b8278d9f475e |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T00:37:20Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-9b7bd7a63c294e9f9871b8278d9f475e2023-09-15T09:28:59ZengWileyAdvanced Science2198-38442023-09-011026n/an/a10.1002/advs.202302702Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone ScaffoldsJuncen Zhou0Elias Georgas1Yingchao Su2Jiayi Zhou3Nadja Kröger4Felix Benn5Alexander Kopp6Yi‐Xian Qin7Donghui Zhu8Department of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USADepartment of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USADepartment of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USADepartment of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USADivision of Plastic‐ Reconstructive‐ and Aesthetic Surgery University Hospital Cologne 50937 Cologne GermanyMeotec GmbH 52068 Aachen GermanyMeotec GmbH 52068 Aachen GermanyDepartment of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USADepartment of Biomedical Engineering University of Stony Brook Stony Brook NY 11794 USAAbstract Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals – the most successful orthopedic material – have yet to yield satisfactory results. Conventional bio‐inert metals, such as titanium (Ti) and its alloys, are widely used for fixation devices and reconstructive implants, but their non‐bioresorbable nature and the mechanical property mismatch with human bones limit their application as porous scaffolds for bone regeneration. Advancements in additive manufacturing have facilitated the use of bioresorbable metals, including magnesium (Mg), zinc (Zn), and their alloys, as porous scaffolds via Laser Powder Bed Fusion (L‐PBF) technology. This in vivo study presents a comprehensive, side‐by‐side comparative analysis of the interactions between bone regeneration and additively manufactured bio‐inert/bioresorbable metal scaffolds, as well as their therapeutic outcomes. The research offers an in‐depth understanding of the metal scaffold‐assisted bone healing process, illustrating that Mg and Zn scaffolds contribute to the bone healing process in distinct ways, but ultimately deliver superior therapeutic outcomes compared to Ti scaffolds. These findings suggest that bioresorbable metal scaffolds hold considerable promise for the clinical treatment of bone defects in the near future.https://doi.org/10.1002/advs.202302702additive manufacturingbioresorbable scaffoldbone regenerationmagnesium alloyzinc alloy |
| spellingShingle | Juncen Zhou Elias Georgas Yingchao Su Jiayi Zhou Nadja Kröger Felix Benn Alexander Kopp Yi‐Xian Qin Donghui Zhu Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds Advanced Science additive manufacturing bioresorbable scaffold bone regeneration magnesium alloy zinc alloy |
| title | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds |
| title_full | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds |
| title_fullStr | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds |
| title_full_unstemmed | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds |
| title_short | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds |
| title_sort | evolution from bioinert to bioresorbable in vivo comparative study of additively manufactured metal bone scaffolds |
| topic | additive manufacturing bioresorbable scaffold bone regeneration magnesium alloy zinc alloy |
| url | https://doi.org/10.1002/advs.202302702 |
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