On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators
Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that continues to develop new variants. A crucial step in the quest to reduce the infection is the development of rapid and reliable virus detectors. Here, we report a chip scale photonic sensing device consisting of a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-03-01
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| Series: | Nanophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/nanoph-2022-0722 |
| _version_ | 1797752422959939584 |
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| author | Grosman Arieh Duanis-Assaf Tal Mazurski Noa Zektzer Roy Frydendahl Christian Stern Liron Reches Meital Levy Uriel |
| author_facet | Grosman Arieh Duanis-Assaf Tal Mazurski Noa Zektzer Roy Frydendahl Christian Stern Liron Reches Meital Levy Uriel |
| author_sort | Grosman Arieh |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that continues to develop new variants. A crucial step in the quest to reduce the infection is the development of rapid and reliable virus detectors. Here, we report a chip scale photonic sensing device consisting of a silicon-nitride double microring resonator (MRR) for detecting SARS-CoV-2 in clinical samples. The sensor is implemented by surface activation of one of the MRRs, acting as a probe, with DNA primers for SARS-CoV-2 RNA, whereas the other MRR is used as a reference. The performance of the sensor is determined by applying different amounts of SARS-CoV-2 complementary RNA. As will be shown in the paper, our device detects the RNA fragments at concentrations of 10 cp/μL and with sensitivity of 750 nm/RIU. As such, it shows a promise toward the implementation of label-free, small form factor, CMOS compatible biosensor for SARS-CoV-2, which is also environment, temperature, and pressure independent. Our approach can also be used for detecting other SARS-CoV-2 genes, as well as other viruses and pathogens. |
| first_indexed | 2024-03-12T17:04:11Z |
| format | Article |
| id | doaj.art-9b7e2a533d4e4ee29888151fd8891119 |
| institution | Directory Open Access Journal |
| issn | 2192-8606 2192-8614 |
| language | English |
| last_indexed | 2024-03-12T17:04:11Z |
| publishDate | 2023-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj.art-9b7e2a533d4e4ee29888151fd88911192023-08-07T06:56:53ZengDe GruyterNanophotonics2192-86062192-86142023-03-0112142831283910.1515/nanoph-2022-0722On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonatorsGrosman Arieh0Duanis-Assaf Tal1Mazurski Noa2Zektzer Roy3Frydendahl Christian4Stern Liron5Reches Meital6Levy Uriel7Department of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelThe Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelDepartment of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelDepartment of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelDepartment of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelDepartment of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelThe Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelDepartment of Applied Physics, The Benin School of Engineering and Computer Science, The Hebrew University of Jerusalem, 91904, Jerusalem, IsraelCoronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that continues to develop new variants. A crucial step in the quest to reduce the infection is the development of rapid and reliable virus detectors. Here, we report a chip scale photonic sensing device consisting of a silicon-nitride double microring resonator (MRR) for detecting SARS-CoV-2 in clinical samples. The sensor is implemented by surface activation of one of the MRRs, acting as a probe, with DNA primers for SARS-CoV-2 RNA, whereas the other MRR is used as a reference. The performance of the sensor is determined by applying different amounts of SARS-CoV-2 complementary RNA. As will be shown in the paper, our device detects the RNA fragments at concentrations of 10 cp/μL and with sensitivity of 750 nm/RIU. As such, it shows a promise toward the implementation of label-free, small form factor, CMOS compatible biosensor for SARS-CoV-2, which is also environment, temperature, and pressure independent. Our approach can also be used for detecting other SARS-CoV-2 genes, as well as other viruses and pathogens.https://doi.org/10.1515/nanoph-2022-0722biosensorscovid-19micro ring resonator; nanophotonics; silicon-photonics; si3n4 |
| spellingShingle | Grosman Arieh Duanis-Assaf Tal Mazurski Noa Zektzer Roy Frydendahl Christian Stern Liron Reches Meital Levy Uriel On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators Nanophotonics biosensors covid-19 micro ring resonator; nanophotonics; silicon-photonics; si3n4 |
| title | On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators |
| title_full | On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators |
| title_fullStr | On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators |
| title_full_unstemmed | On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators |
| title_short | On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators |
| title_sort | on chip multivariant covid 19 photonic sensor based on silicon nitride double microring resonators |
| topic | biosensors covid-19 micro ring resonator; nanophotonics; silicon-photonics; si3n4 |
| url | https://doi.org/10.1515/nanoph-2022-0722 |
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