Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i>
Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer’s disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since a...
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/4/1826 |
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| author | Denia Cai Shi Chunlin Long Ella Vardeman Edward J. Kennelly Michael A. Lawton Rong Di |
| author_facet | Denia Cai Shi Chunlin Long Ella Vardeman Edward J. Kennelly Michael A. Lawton Rong Di |
| author_sort | Denia Cai Shi |
| collection | DOAJ |
| description | Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer’s disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since amyloid-β toxicity is known to cause oxidative stress and damage to brain cells, we hypothesized that mogrosides may have a protective effect against AD. In this study, we investigated the potential anti-AD effect of mogrosides in vitamin B12-deficient wild-type N2 and in transgenic CL2355 <i>Caenorhabditis elegans</i> expressing amyloid-β peptide. Our data indicated that mogrosides have a beneficial effect on the lifespan and egg-laying rate of N2 and vitamin B12-deficient N2 worms. Additionally, the results revealed that mogrosides can effectively delay the paralysis of CL2355 worms as determined by serotonin sensitivity assay. Our analysis showed that mogrosides increase the expression of oxidative protective genes in N2 worms fed with vitamin B12-deficient OP50 bacterium. We conclude that mogrosides may exert preventative rather than curative effects that counteract the detrimental vitamin B12-deficient environment in N2 and CL2355 <i>C. elegans</i> by modulating oxidation-related gene expression. |
| first_indexed | 2024-03-11T08:21:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T08:21:10Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9b7eb2ed892b433f8326017123d356052023-11-16T22:23:46ZengMDPI AGMolecules1420-30492023-02-01284182610.3390/molecules28041826Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i>Denia Cai Shi0Chunlin Long1Ella Vardeman2Edward J. Kennelly3Michael A. Lawton4Rong Di5New Brunswick Graduate School, Rutgers University, New Brunswick, NJ 08901, USACollege of Life and Environmental Sciences, Minzu University of China, Beijing 100086, ChinaGraduate Center, City University of New York, 365 5th Ave, New York, NY 10016, USAGraduate Center, City University of New York, 365 5th Ave, New York, NY 10016, USADepartment of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USADepartment of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USAVitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer’s disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since amyloid-β toxicity is known to cause oxidative stress and damage to brain cells, we hypothesized that mogrosides may have a protective effect against AD. In this study, we investigated the potential anti-AD effect of mogrosides in vitamin B12-deficient wild-type N2 and in transgenic CL2355 <i>Caenorhabditis elegans</i> expressing amyloid-β peptide. Our data indicated that mogrosides have a beneficial effect on the lifespan and egg-laying rate of N2 and vitamin B12-deficient N2 worms. Additionally, the results revealed that mogrosides can effectively delay the paralysis of CL2355 worms as determined by serotonin sensitivity assay. Our analysis showed that mogrosides increase the expression of oxidative protective genes in N2 worms fed with vitamin B12-deficient OP50 bacterium. We conclude that mogrosides may exert preventative rather than curative effects that counteract the detrimental vitamin B12-deficient environment in N2 and CL2355 <i>C. elegans</i> by modulating oxidation-related gene expression.https://www.mdpi.com/1420-3049/28/4/1826mogrosidesAlzheimer’s diseasevitamin B12 deficiency<i>Caenorhabditis elegans</i> |
| spellingShingle | Denia Cai Shi Chunlin Long Ella Vardeman Edward J. Kennelly Michael A. Lawton Rong Di Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> Molecules mogrosides Alzheimer’s disease vitamin B12 deficiency <i>Caenorhabditis elegans</i> |
| title | Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> |
| title_full | Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> |
| title_fullStr | Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> |
| title_short | Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient <i>Caenorhabditis elegans</i> |
| title_sort | potential anti alzheimer properties of mogrosides in vitamin b12 deficient i caenorhabditis elegans i |
| topic | mogrosides Alzheimer’s disease vitamin B12 deficiency <i>Caenorhabditis elegans</i> |
| url | https://www.mdpi.com/1420-3049/28/4/1826 |
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