The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue

The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue

Abstract Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate t...

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Bibliographic Details
Main Authors: Mary E. Sehl, Jill E. Henry, Anna Maria Storniolo, Steve Horvath, Patricia A. Ganz
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00410-4

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