Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with...
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.669552/full |
| _version_ | 1818944009539682304 |
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| author | Mengfan Jiao Mengfan Jiao Xiang Deng Hongfu Yang Junqiang Dong Jun Lv Fang Li |
| author_facet | Mengfan Jiao Mengfan Jiao Xiang Deng Hongfu Yang Junqiang Dong Jun Lv Fang Li |
| author_sort | Mengfan Jiao |
| collection | DOAJ |
| description | Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with pneumonia, sepsis and intermuscular abscesses induced by Nocardia farcinica. Venous blood culture reported negative results. Former improper diagnosis and treatment did not improve his condition. With the assistant of metagenomic next-generation sequencing, the pathogen was identified as Nocardia farcinica. He was then applied with accurate treatment and had a remarkable clinical and radiological improvement. |
| first_indexed | 2024-12-20T07:36:24Z |
| format | Article |
| id | doaj.art-9b80084a24014b9cb75d5ce7680856a6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T07:36:24Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-9b80084a24014b9cb75d5ce7680856a62022-12-21T19:48:17ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-05-01810.3389/fmed.2021.669552669552Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation SequencingMengfan Jiao0Mengfan Jiao1Xiang Deng2Hongfu Yang3Junqiang Dong4Jun Lv5Fang Li6Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaPrecision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Integrated Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Imaging and Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with pneumonia, sepsis and intermuscular abscesses induced by Nocardia farcinica. Venous blood culture reported negative results. Former improper diagnosis and treatment did not improve his condition. With the assistant of metagenomic next-generation sequencing, the pathogen was identified as Nocardia farcinica. He was then applied with accurate treatment and had a remarkable clinical and radiological improvement.https://www.frontiersin.org/articles/10.3389/fmed.2021.669552/fullcase reportNocardiametagenomics next-generation sequencingprecise treatmentinfectious disease |
| spellingShingle | Mengfan Jiao Mengfan Jiao Xiang Deng Hongfu Yang Junqiang Dong Jun Lv Fang Li Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing Frontiers in Medicine case report Nocardia metagenomics next-generation sequencing precise treatment infectious disease |
| title | Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing |
| title_full | Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing |
| title_fullStr | Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing |
| title_full_unstemmed | Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing |
| title_short | Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing |
| title_sort | case report a severe and multi site nocardia farcinica infection rapidly and precisely identified by metagenomic next generation sequencing |
| topic | case report Nocardia metagenomics next-generation sequencing precise treatment infectious disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.669552/full |
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