A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans.
A cell's size affects the likelihood that it will die. But how is cell size controlled in this context and how does cell size impact commitment to the cell death fate? We present evidence that the caspase CED-3 interacts with the RhoGEF ECT-2 in Caenorhabditis elegans neuroblasts that generate...
Main Authors: | Aditya Sethi, Hai Wei, Nikhil Mishra, Ioannis Segos, Eric J Lambie, Esther Zanin, Barbara Conradt |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-10-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3001786 |
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