A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus
This study include the investigative the effect of Dexamethasone on the lung development and External morphology features at early Embryonic Developmental stages and evaluate Alpha Fetoprotein levels .Sixty pregnant mice were randomly divided into four groups and each group include 15 pregnant m...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-04-01
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| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://www.jsci.utq.edu.iq/index.php/main/article/view/15 |
| _version_ | 1797595826288066560 |
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| author | Ali Naeem Salman Sada Ghaleb Taher Al- Musawi |
| author_facet | Ali Naeem Salman Sada Ghaleb Taher Al- Musawi |
| author_sort | Ali Naeem Salman |
| collection | DOAJ |
| description | This study include the investigative the effect of Dexamethasone on the lung development and External morphology features at early Embryonic Developmental stages and evaluate Alpha Fetoprotein levels .Sixty pregnant mice were randomly divided into four groups and each group include 15 pregnant mice. Given the members of each group specific dose of (Dex) and at different time periods, while the control group injected with a solution of Normal Saline 0.9%, all animals received doses used by tail intravenous injection. In the end of specific period of pregnancy embryos were isolated from mothers ,mother's blood were taken to evaluate AFP levels .The results of statistical analysis at (P < 0.05) to different doses Dexamethasone show there a negative effects on mice embryo's body weights and the lengths increase with increasing of number and doses concentrations, (Dex) also affected on general external morphological features in embryos and on their lung development ,Dex has been affected on the lung development through lung cell proliferation and activity, especially at long terms and repeated doses.It's has been caused congenital malformations in embryos: Death of embryos ,placenta damage ,neural Tube Defect ,Trunk Torsion ,Head hemorrhage, Brain hypertrophy ,Liver Hypertrophy ,Letter C Shape Embryos, swelling ,Convoluted Tail ,Short limbs.The Altered in the AFP levels have been observed concurred with aberrant growth manifestations .
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| first_indexed | 2024-03-11T02:42:55Z |
| format | Article |
| id | doaj.art-9b86b8a50bd4409c96936a837ee7c842 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-11T02:42:55Z |
| publishDate | 2019-04-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-9b86b8a50bd4409c96936a837ee7c8422023-11-18T09:30:30ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-04-0162A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus Ali Naeem Salman0Sada Ghaleb Taher Al- Musawi1Collage of Nursing /Thi-Qar University Department of Biology / Collage of education for pure science /Thi-Qar UniversityThis study include the investigative the effect of Dexamethasone on the lung development and External morphology features at early Embryonic Developmental stages and evaluate Alpha Fetoprotein levels .Sixty pregnant mice were randomly divided into four groups and each group include 15 pregnant mice. Given the members of each group specific dose of (Dex) and at different time periods, while the control group injected with a solution of Normal Saline 0.9%, all animals received doses used by tail intravenous injection. In the end of specific period of pregnancy embryos were isolated from mothers ,mother's blood were taken to evaluate AFP levels .The results of statistical analysis at (P < 0.05) to different doses Dexamethasone show there a negative effects on mice embryo's body weights and the lengths increase with increasing of number and doses concentrations, (Dex) also affected on general external morphological features in embryos and on their lung development ,Dex has been affected on the lung development through lung cell proliferation and activity, especially at long terms and repeated doses.It's has been caused congenital malformations in embryos: Death of embryos ,placenta damage ,neural Tube Defect ,Trunk Torsion ,Head hemorrhage, Brain hypertrophy ,Liver Hypertrophy ,Letter C Shape Embryos, swelling ,Convoluted Tail ,Short limbs.The Altered in the AFP levels have been observed concurred with aberrant growth manifestations . https://www.jsci.utq.edu.iq/index.php/main/article/view/15Dexamethasonelung developmentAlbino Mice EmbryosAFP |
| spellingShingle | Ali Naeem Salman Sada Ghaleb Taher Al- Musawi A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus مجلة علوم ذي قار Dexamethasone lung development Albino Mice Embryos AFP |
| title | A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus |
| title_full | A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus |
| title_fullStr | A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus |
| title_full_unstemmed | A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus |
| title_short | A Study of the effect of Dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos Mus masculus |
| title_sort | study of the effect of dexamethasone on the lung development and external morphology features during early embryonic stages in the swiss albino mice embryos mus masculus |
| topic | Dexamethasone lung development Albino Mice Embryos AFP |
| url | https://www.jsci.utq.edu.iq/index.php/main/article/view/15 |
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