Modern neuroprotection in pediatrics
The article deals with the main mechanisms of neuroprotectors action and modern strategies of neuroprotection. It is proved that the effectiveness of neuroprotectors is primarily due to the anti-excitotoxic effect, interruption of rapid reactions of the glutamate-calcium cascade, blockade of pro-inf...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2020-10-01
|
| Series: | Zdorovʹe Rebenka |
| Subjects: | |
| Online Access: | http://childshealth.zaslavsky.com.ua/article/view/215531 |
| Summary: | The article deals with the main mechanisms of neuroprotectors action and modern strategies of neuroprotection. It is proved that the effectiveness of neuroprotectors is primarily due to the anti-excitotoxic effect, interruption of rapid reactions of the glutamate-calcium cascade, blockade of pro-inflammatory cytokines and adhesion molecules, inhibition of pro-oxidant enzymes, increased trophic supply, prevention of apoptosis. The neuroprotective properties of complex drugs Silenta and Kogivis are described. Their high efficiency in pediatrics is due to the potentiation of the action of their components, and safety is due to the low doses of each of the components. |
|---|---|
| ISSN: | 2224-0551 2307-1168 |