Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases
MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs w...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/6/1345 |
| _version_ | 1827716095377670144 |
|---|---|
| author | Albin John Aaron Kubosumi P. Hemachandra Reddy |
| author_facet | Albin John Aaron Kubosumi P. Hemachandra Reddy |
| author_sort | Albin John |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases. |
| first_indexed | 2024-03-10T19:32:53Z |
| format | Article |
| id | doaj.art-9b8935b4d65e430e829d51fd04e7ccdd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:32:53Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9b8935b4d65e430e829d51fd04e7ccdd2023-11-20T02:01:15ZengMDPI AGCells2073-44092020-05-0196134510.3390/cells9061345Mitochondrial MicroRNAs in Aging and Neurodegenerative DiseasesAlbin John0Aaron Kubosumi1P. Hemachandra Reddy2Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USAMicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.https://www.mdpi.com/2073-4409/9/6/1345microRNAsmitochondrial microRNAsagingAlzheimer’s diseaseParkinson’s diseaseHuntington’s disease |
| spellingShingle | Albin John Aaron Kubosumi P. Hemachandra Reddy Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases Cells microRNAs mitochondrial microRNAs aging Alzheimer’s disease Parkinson’s disease Huntington’s disease |
| title | Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases |
| title_full | Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases |
| title_fullStr | Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases |
| title_full_unstemmed | Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases |
| title_short | Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases |
| title_sort | mitochondrial micrornas in aging and neurodegenerative diseases |
| topic | microRNAs mitochondrial microRNAs aging Alzheimer’s disease Parkinson’s disease Huntington’s disease |
| url | https://www.mdpi.com/2073-4409/9/6/1345 |
| work_keys_str_mv | AT albinjohn mitochondrialmicrornasinagingandneurodegenerativediseases AT aaronkubosumi mitochondrialmicrornasinagingandneurodegenerativediseases AT phemachandrareddy mitochondrialmicrornasinagingandneurodegenerativediseases |