Liquid–liquid phase separation in human health and diseases
Abstract Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indica...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-08-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-021-00678-1 |
| _version_ | 1818363582781325312 |
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| author | Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou |
| author_facet | Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou |
| author_sort | Bin Wang |
| collection | DOAJ |
| description | Abstract Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its physiological functions. We further describe the role of LLPS in the development of human diseases. Additionally, we review the recently developed methods for studying LLPS. Although LLPS research is in its infancy—but is fast-growing—it is clear that LLPS plays an essential role in the development of pathophysiological conditions. This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries. |
| first_indexed | 2024-12-13T21:50:46Z |
| format | Article |
| id | doaj.art-9b89b0f462b14e3bbc79aef6962cd811 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-12-13T21:50:46Z |
| publishDate | 2021-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-9b89b0f462b14e3bbc79aef6962cd8112022-12-21T23:30:18ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-08-016111610.1038/s41392-021-00678-1Liquid–liquid phase separation in human health and diseasesBin Wang0Lei Zhang1Tong Dai2Ziran Qin3Huasong Lu4Long Zhang5Fangfang Zhou6Department of Orthopaedic Surgery, The Third Affiliated Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Third Affiliated Hospital of Wenzhou Medical UniversityInstitutes of Biology and Medical Science, Soochow UniversityMOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang UniversityMOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang UniversityMOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang UniversityInstitutes of Biology and Medical Science, Soochow UniversityAbstract Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its physiological functions. We further describe the role of LLPS in the development of human diseases. Additionally, we review the recently developed methods for studying LLPS. Although LLPS research is in its infancy—but is fast-growing—it is clear that LLPS plays an essential role in the development of pathophysiological conditions. This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.https://doi.org/10.1038/s41392-021-00678-1 |
| spellingShingle | Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou Liquid–liquid phase separation in human health and diseases Signal Transduction and Targeted Therapy |
| title | Liquid–liquid phase separation in human health and diseases |
| title_full | Liquid–liquid phase separation in human health and diseases |
| title_fullStr | Liquid–liquid phase separation in human health and diseases |
| title_full_unstemmed | Liquid–liquid phase separation in human health and diseases |
| title_short | Liquid–liquid phase separation in human health and diseases |
| title_sort | liquid liquid phase separation in human health and diseases |
| url | https://doi.org/10.1038/s41392-021-00678-1 |
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