Immunological aspects of ovarian malignancy
Objective: Evidence shows that the host’s immune system interacts with tumor development and may be responsible for delaying tumor growth or even for its progression. Chronic inflammation has been identified as a key factor in the pathogenesis of ovarian cancer. The objective of this study is to car...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902035 |
| _version_ | 1818201292053413888 |
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| author | Agrimaldo Martins-Filho Millena Prata Jammal Eddie Fernando Candido Murta Rosekeila Simões Nomelini |
| author_facet | Agrimaldo Martins-Filho Millena Prata Jammal Eddie Fernando Candido Murta Rosekeila Simões Nomelini |
| author_sort | Agrimaldo Martins-Filho |
| collection | DOAJ |
| description | Objective: Evidence shows that the host’s immune system interacts with tumor development and may be responsible for delaying tumor growth or even for its progression. Chronic inflammation has been identified as a key factor in the pathogenesis of ovarian cancer. The objective of this study is to carry out a comprehensive review of immunological aspects of ovarian cancer. Mechanism: A search of the following keywords was conducted in the PubMed database: “ovarian cancer”, “prognostic factors”, “immunotherapy”, “immune system”. The articles identified were published between 1992 and 2021. Findings in brief: A total of 75 articles were selected for further examination. Conclusions: The understanding of tumor immune escape mechanisms will improve immunotherapy treatments. This will allow personalization or treatment not only in accordance with the biology of the tumor, but also with the characteristics of the tumor microenvironment, expanding the benefit of immunotherapy and providing more effective responses. |
| first_indexed | 2024-12-12T02:51:14Z |
| format | Article |
| id | doaj.art-9b8c44a401174a4daf9b87fa823d8483 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T02:51:14Z |
| publishDate | 2022-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-9b8c44a401174a4daf9b87fa823d84832022-12-22T00:40:53ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-02-014923510.31083/j.ceog4902035S0390-6663(22)01684-0Immunological aspects of ovarian malignancyAgrimaldo Martins-Filho0Millena Prata Jammal1Eddie Fernando Candido Murta2Rosekeila Simões Nomelini3Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba-MG, BrazilResearch Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba-MG, BrazilResearch Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba-MG, BrazilResearch Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba-MG, BrazilObjective: Evidence shows that the host’s immune system interacts with tumor development and may be responsible for delaying tumor growth or even for its progression. Chronic inflammation has been identified as a key factor in the pathogenesis of ovarian cancer. The objective of this study is to carry out a comprehensive review of immunological aspects of ovarian cancer. Mechanism: A search of the following keywords was conducted in the PubMed database: “ovarian cancer”, “prognostic factors”, “immunotherapy”, “immune system”. The articles identified were published between 1992 and 2021. Findings in brief: A total of 75 articles were selected for further examination. Conclusions: The understanding of tumor immune escape mechanisms will improve immunotherapy treatments. This will allow personalization or treatment not only in accordance with the biology of the tumor, but also with the characteristics of the tumor microenvironment, expanding the benefit of immunotherapy and providing more effective responses.https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902035ovarian cancerprognostic factorsimmunotherapyimmune system |
| spellingShingle | Agrimaldo Martins-Filho Millena Prata Jammal Eddie Fernando Candido Murta Rosekeila Simões Nomelini Immunological aspects of ovarian malignancy Clinical and Experimental Obstetrics & Gynecology ovarian cancer prognostic factors immunotherapy immune system |
| title | Immunological aspects of ovarian malignancy |
| title_full | Immunological aspects of ovarian malignancy |
| title_fullStr | Immunological aspects of ovarian malignancy |
| title_full_unstemmed | Immunological aspects of ovarian malignancy |
| title_short | Immunological aspects of ovarian malignancy |
| title_sort | immunological aspects of ovarian malignancy |
| topic | ovarian cancer prognostic factors immunotherapy immune system |
| url | https://www.imrpress.com/journal/CEOG/49/2/10.31083/j.ceog4902035 |
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