siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model

siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model

Diabetes mellitus is a metabolic disease that can produce different alterations such as endothelial dysfunction, which is defined as a decrease in the vasodilator responses of the mechanisms involved such as the nitric oxide (NO) pathway. The overexpression of PDE5A has been reported in diabetes, wh...

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Bibliographic Details
Main Authors: Vanessa Giselle Garcia-Rubio, Sandra Edith Cabrera-Becerra, Sergio Adrian Ocampo-Ortega, Citlali Margarita Blancas-Napoles, Vivany Maydel Sierra-Sánchez, Rodrigo Romero-Nava, Rocío Alejandra Gutiérrez-Rojas, Fengyang Huang, Enrique Hong, Santiago Villafaña
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Scientia Pharmaceutica
Subjects:
diabetes
PDE5A-siRNA
endothelial dysfunction
PDE5A mRNA
vasodilation
Online Access:https://www.mdpi.com/2218-0532/91/4/52

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